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中国生物医学工程学会
北京玛格泰克科技发展有限公司
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2018 Vol. 27, No. 1
Published: 2018-03-01
Research papers
Research papers
1
Pitch Perception Assessed by Frequency Difference Limen and Frequency Following Response
GONG Qin, XU Qin, SUN Wen-sheng
The improvement of pitch perception is a hot spot in cochlear implant algorithm research. In order to provide objective and effective guidance for the algorithm research, psychoacoustic method and brainstem frequency following response (FFR) were studied in this paper to assess the ability of pitch perception among young people who exhibited the same normal hearing sensitivity. Eleven Chinese college students participated in both the psychoacoustic experiment and FFR experiment. Using pure tone as the stimulus, psychoacoustic frequency difference limen (FDL) and FFR neural pitch strength were measured. Both of them were used as parameters for evaluating pitch perception ability. FFR pitch strengths were extracted by three different methods which were autocorrelation, chirp z-transform and spectrogram. FFR pitch strengths correlated to a certain extent with FDL results and the FFR pitch strength by autocorrelation showed the highest degree of correlation. The results imply that in the same normal hearing population, features extracted from FFR signal can represent pitch perception ability of subjects. FFR features can be expected to become objective and effective parameters for assessing cochlear implant algorithms.
2018 Vol. 27 (1): 1-8 [
Abstract
] (
22
)
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(1 KB)
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(3363 KB) (
102
)
9
Localization of Fluorescent Substance in Scatting Turbid Media: Simulation and Phantom Validation
LIAO Hong-en, WANG Shuai, Takehiro Ando, Etsuko Kobayashi, Ichiro Sakuma
We proposed a method to identify spatial position of fluorescent substance in living body. With the assumption that cancerous lesion has been successfully targeted by a specific exogenous fluorescent probe, the objective of this study is to seek a straightforward and simple solution for localizing fluorescent material inside scattering turbid media. Our method enables estimation of horizontal position and depth of the fluorescent substance. A fluorescence detection system and corresponding simulation method are also developed to evaluate the proposed method. The phantom experimental results showed that the fluorescence produced by the fluorescent substance in scattering medium that simulates the adipose tissue could be detected. The fluorescence localizing can provide more precision position information to surgeons as to whether resection of certain parts of stomach is necessary. This method is possible to be used in gastric cancer diagnosis, therefore helping to reduce over-resection.
2018 Vol. 27 (1): 9-15 [
Abstract
] (
22
)
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(1 KB)
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(3318 KB) (
96
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16
In vitro
and
in vivo
Evaluation of TONGXIN LVAD
LIN Chang-yan, WU Guang-hui, HOU Xiao-tong, LI Hai-yan, LIU Xiu-jian, XU Chuang-ye, WANG Jin, CHEN Chen
Background:
Tongxin left ventricular assist device (LVAD), an implantable magnetic suspending VAD developed in China Heart Biomedical Incorporation aiming for clinical use, weighs about 350 g and can deliver 6 L/min for pressures of 145 mmHg at 2500 rpm.
Objective:
This study aims to investigate the implantation possibility, hemolysis and hemocompatibility of the LVAD before clinic use.
Methods:
The tests of implantation possibility, hemolysis and hemocompatibility to the LVAD were completed by fitting study, hemolysis test and in
vivo
experiments respectively. Meanwhile the hemolysis was evaluated by the amount of free hemoglobin in plasma and studied using the normalized index of hemolysis (NIH).
Results:
The fitting study showed that the blood pump could be implanted in the sheep heart chambers without squeezing the surrounding organs by comparing the preoperative and the postoperative chest X-ray. The NIH value of Tongxin LVAD was (0.00750±0017) g/100 L
in vitro
hemolysis test. Two sheep
in vivo
experiments showed the hemolysis
in vivo
was below 7.5 mg/dL. Hematologic and biochemical test results were within normal limits during the study period. There were no significant complications. Postmortem examination of the explanted organs revealed no evidence of microemboli, ischemia or infarction. The pump's inflow and outflow conduits were free of thrombus.
Conclusion:
These results indicated that the implantable magnetic suspending LVAD showed exceptional implantation possibility, hemolysis and hemocompatibility, which are crucial to the clinical success of this implantable LVAD.
2018 Vol. 27 (1): 16-22 [
Abstract
] (
21
)
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(1 KB)
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(3552 KB) (
86
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23
Synthesis and Characterization of High-Transparent Poly (vinyl alcohol) / Poly(vinyl pyrrolidone) (PVA/PVP) Hydrogels
XU Yi, ZHOU Gang, LIU Lei, LIU Hong-ru, LIU Hai-feng, NIU Xu-feng, FAN Yu-bo
In this paper, transparent poly(vinyl alcohol) / poly(vinyl pyrrolidone) (PVA/PVP) hydrogels were prepared by using the solvent of dimethyl sulfoxide (DMSO) aqueous solution and the method of freeze/thawing. The effect of PVP interaction, mechanical property and transparence of PVA/PVP hydrogel was investigated and evaluated by FT-IR analysis, mechanical test machine and UV spectrophotometer. The results showed that when the content of PVP was 8% in the DMSO aqueous solution, the highest transparence of PVA/PVP hydrogel was obtained, with excellent tensile strength values higher than 3.5 MPa. Therefore, the PVA/PVP hydrogel composite has a potential to be used as the transparent core of a novel artificial cornea.
2018 Vol. 27 (1): 23-27 [
Abstract
] (
7
)
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(1 KB)
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(2293 KB) (
92
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28
A Personal Wireless System for Cardiovascular Monitoring
YANG Pan, PAN Qing, LIN Chang-yu, ZHOU Jia, FU Xiao, LI Li, GONG Shi-jin, YAN Jing, NING Gang-min
Chronic diseases, especially cardiovascular diseases, have become one of the leading health problems in China. For preventing cardiovascular diseases and improving treatment, it is necessary to regularly monitor vascular status related physiological signals at home. We designed a home-used wireless system for daily monitoring cardiovascular condition. Vital physiological signs are obtained by a chair-based measurement apparatus and then transmitted by bluetooth. Finally, these data are delivered to a remote healthcare server through internet. General practitioners can analyze the related indices and make an electronic report to users, who can check health status and understand cardiovascular risks.
2018 Vol. 27 (1): 28-32 [
Abstract
] (
9
)
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111
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33
Biomechanical Properties of Transplanted Xenogenic Meniscal Tissue
ZHAO Feng, JIANG Dong, FAN Yu-bo, YU Jia-kuo
The clinical repair approaches to meniscal lesions include total or subtotal meniscectomy, transplantation, and tissue engineering. The investigations found that the transplanted xenogenic meniscal tissues, which were treated by
60
Co irradiation and deep freezing, maybe one of the effective approaches. In this paper, we evaluated the biomechanical properties of the transplanted xenogenic meniscal tissues at postoperative 1 year.
In vitro
tensile and compressive tests are performed to compare the properties of tensile elasticity, tensile strength, and compressive elasticcity, between three groups: RAB group of normal rabbit meniscus tissue, Allo group of transplanted allograft meniscal tissue, and Xeno group of transplanted xenogenic meniscal tissue. The meniscus of the Xeno group showed similar tension and compression modulus as the native rabbit meniscus without significant difference(
p
>0.05), and the tension strength of both the Xeno group and the Allo group were less than that of the native rabbit meniscus (0.05<
p
<0.1). No significant difference was found between the Xeno group and the Allo group with regard to each biomechanical parameter (
p
>0.05). These base studies will be helpful in future transplantation and tissue engineering efforts.
2018 Vol. 27 (1): 33-39 [
Abstract
] (
12
)
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(1 KB)
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(3497 KB) (
81
)
40
Detection of Bacteria Based on Quantum Dots by Using a Laboratory-Made System
CHENG Zhi, WU Tai-hu, CHEN Feng, DU Yao-hua, GU Biao, LI Chao, YANG Zi-jian
This study investigated a method that simultaneously detects three bacteria, Salmonella typhimurium, Escherichia coli, and Staphylococcus aureus via an approach that uses antibody-conjugated quantum dots (QDs) as fluorescence markers, by using a laboratory-made system. QDs with different emission wavelenghs were immobilized with antibody. Antibody conjugated QDs capture the bacteria selectively and specifically so that "sandwich" complex were formed. The suspension of the labeled bacteria was trickled onto a microporous membrane. A 450 nm semiconductor laser was used as a part of the laboratory-made system to excite the QDs. Three PMT detectors were utilized to detect the fluorescence intensity. This method, of which the detection procedures are completed within 1 h, can be applied to the cost-effective and rapid detecting of bacterial contamination.
2018 Vol. 27 (1): 40-46 [
Abstract
] (
15
)
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(1 KB)
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(3523 KB) (
130
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