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| Localization of Fluorescent Substance in Scatting Turbid Media: Simulation and Phantom Validation |
| LIAO Hong-en1,2, WANG Shuai1, Takehiro Ando1, Etsuko Kobayashi1,2, Ichiro Sakuma1,2 |
1. Graduate School of Engineering, The University of Tokyo, Tokyo, Japan;
2. Translational Systems Biology and Medicine Initiative, The University of Tokyo, Tokyo, Japan |
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Abstract We proposed a method to identify spatial position of fluorescent substance in living body. With the assumption that cancerous lesion has been successfully targeted by a specific exogenous fluorescent probe, the objective of this study is to seek a straightforward and simple solution for localizing fluorescent material inside scattering turbid media. Our method enables estimation of horizontal position and depth of the fluorescent substance. A fluorescence detection system and corresponding simulation method are also developed to evaluate the proposed method. The phantom experimental results showed that the fluorescence produced by the fluorescent substance in scattering medium that simulates the adipose tissue could be detected. The fluorescence localizing can provide more precision position information to surgeons as to whether resection of certain parts of stomach is necessary. This method is possible to be used in gastric cancer diagnosis, therefore helping to reduce over-resection.
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Received: 12 December 2017
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| Fund:Grant-in-Aid for Scientific Research of JSPS; grant number: 23680049 |
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Corresponding Authors:
LIAO Hong-en. E-mail: liao@bmpe.t.u-tokyo.ac.jp
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