Biomechanical Properties of Transplanted Xenogenic Meniscal Tissue

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Abstract The clinical repair approaches to meniscal lesions include total or subtotal meniscectomy, transplantation, and tissue engineering. The investigations found that the transplanted xenogenic meniscal tissues, which were treated by ⁶⁰Co irradiation and deep freezing, maybe one of the effective approaches. In this paper, we evaluated the biomechanical properties of the transplanted xenogenic meniscal tissues at postoperative 1 year. In vitro tensile and compressive tests are performed to compare the properties of tensile elasticity, tensile strength, and compressive elasticcity, between three groups: RAB group of normal rabbit meniscus tissue, Allo group of transplanted allograft meniscal tissue, and Xeno group of transplanted xenogenic meniscal tissue. The meniscus of the Xeno group showed similar tension and compression modulus as the native rabbit meniscus without significant difference(p>0.05), and the tension strength of both the Xeno group and the Allo group were less than that of the native rabbit meniscus (0.05<p<0.1). No significant difference was found between the Xeno group and the Allo group with regard to each biomechanical parameter (p>0.05). These base studies will be helpful in future transplantation and tissue engineering efforts.

Key words： biomechanics xenogenic meniscus transplantation Young's modulus strength

Received: 12 January 2018

PACS:

TP 273

Fund:National Natural Science Foundation of China; grant number: 11072021, 31170895

Corresponding Authors: ZHAO Feng. E-mail: fzhao@buaa.edu.cn

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	ZHAO Feng
	JIANG Dong
	FAN Yu-bo
	YU Jia-kuo

Cite this article:

ZHAO Feng,JIANG Dong,FAN Yu-bo, et al. Biomechanical Properties of Transplanted Xenogenic Meniscal Tissue[J]. Chinese Journal of Biomedical Engineering, 2018, 27(1): 33-39.

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http://manu32.magtech.com.cn/Jwk_zgswyx_en/EN/ OR http://manu32.magtech.com.cn/Jwk_zgswyx_en/EN/Y2018/V27/I1/33

[1] Messner K, Gao J.The menisci of the knee joint. Anatomicaland functional characteristics, and a rationale for clinical treatment[J]. Journal of Anatomy, 1998, 193(2):161-178.
[2] Englund M, Roos EM, Roos HP, et al.Patient-relevant outcomes fourteen years after meniscectomy: influence of type ofmeniscal tear and size of resection[J]. Rheumatology, 2001, 40(6):631-639.
[3] Klimkiewicz JJ, Shaffer B.Meniscal surgery 2002 update: indications and techniques for resection, repair, regeneration, and replacement[J]. Arthroscopy, 2002, 18(9):14-25.
[4] Longo UG, Loppini M.Advances in meniscal tissue engineering[J]. Stem Cells International, 2012, 420346.
[5] Rangger C, Klestil T, Gloetzer W, et al.Osteoarthritis after arthroscopic partial meniscectomy[J]. The American Journal of Sports Medicine,1995, 23: 240-244.
[6] Buma P, Ramrattan NN, Van Tienen TG, et al.Tissue engineering of the meniscus[J]. Biomaterials, 2004, 25(9):1523-1532.
[7] Locht RC, Gross AE, Langer F.Late osteochondral allograft resurfacing for tibial plateau fractures[J]. Journal of Bone & Joint Surgery American Volume, 1984, 66:328-335.
[8] van Arkel ER, deBoer HH. Human meniscal transplantation[J]. Journal of Bone & Joint Surgery British Volume, 1995, 77:589-595.
[9] Dong Jiang.The experimental study on xenogenic meniscus transplantation[D]. Institute of Sports Medicine, Peking University Third Hospital, 2009.
[10] Proctor CS, Schmidt MB.Material properties of the normal medial bovine memscus[J]. Journal of Orthopaedic Research, 1989, 7:771-782.
[11] Fithian DC, Kelly MA, Mow VC.Material properties and structure-function relationships in the menisci[J]. Clinical Orthopaedics and Related Research, 1990, 252:19-31.
[12] Sweigart MA, Athanasiou KA.Tensile and compressive properties of the medial rabbit meniscus[J]. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, 2005, 219(5): 337-347.