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中国生物医学工程学会
北京玛格泰克科技发展有限公司
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2019 Vol. 28, No. 3
Published: 2019-09-01
Research papers
Review
Research papers
93
Study on the Correlation between the Characteristics of Carotid Plaque and Ischemic Stroke
WANG Qian, LIU Si-bo, LONG An-ni, LIU Jing-zhe, ZHANG Xiao-wei, LI Lei
Objective:
To evaluate the correlation between MRI plaque characteristics and ischemic stroke in patients with carotid artery stenosis ≤ 50%.
Methods:
From September 2014 to February 2016, 43 patients with carotid artery plaque with stenosis less than or equal to 50% were selected by ultrasound. All patients were examined by black blood MRI. The correlation between MRI plaque characteristics and other risk factors and ischemic stroke was evaluated by single factor and multi factor analysis.
Results:
The median follow-up time of all patients was 11.8 months. Kaplan Meier survival analysis showed that the median time of stroke free was significantly shorter in patients with intracoronary hemorrhage than in patients without intracoronary hemorrhage, which was 14.3 months and 18.6 months, respectively (
P
=0.001); the median time of stroke free was also significantly shorter in patients with coronary heart disease than in patients without coronary heart disease, which was 12.1 months and 18.7 months, respectively (
P
=0.029). Cox regression analysis showed that coronary heart disease (HR=27.4; 95%CI, 1.6-464.3;
P
=0.022) and intraplaque hemorrhage (HR=18.2; 95%CI, 2.7-123.3;
P
=0.003) were independent risk factors for ischemic stroke.
Conclusion:
In the patients with carotid artery stenosis ≤ 50%, plaque hemorrhage and coronary heart disease are independent risk factors of ischemic stroke.
2019 Vol. 28 (3): 93-104 [
Abstract
] (
44
)
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149
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105
Establishment of a Fast Quality Assurance Method for Three-dimensional Afterloading Treatment Plan
JI Tian-long, ZHAO Jing, SHEN Hao, LI Guang
Objective:
To study the correlation between tumor size, radiation source intensity, prescription dose, and source dwell time in afterloading treatment plan, and to establish a rapid quality control method for afterloading treatment plan.
Methods:
A total of 181 patients with gynecological tumor were enrolled in our hospital. A total of 84 patients were installed with three tubes of Fletcher' applicator, 58 patients with single uterine tube and 39 patients with vaginal applicator. Each patient was scanned with CT before treatment, and the target area and organs were delineated by doctors. The treatment plan was optimized by IPSA. The planned source intensity, prescription dose, source residence time and tumor volume of each case were recorded and the CI, RV, and k value were calculated, The CI distribution characteristics and the relationship with RV value were analyzed. In addition, 46 cases of gynecological tumor patients' afterloading plan used this method for quality control verification.
Results:
The CI of the three kinds of applicators was normal distribution. The average Ci of Fletcher applicator was 0.720±0.067, k=1394, r=0.894, the average CI of Fletcher applicator was 0.697±0.076, k=1428, r=0.940, the average CI of vaginal applicator was 0.742±0.067, k=1362, r=0.909.
Conclusion:
Using this method, we could quickly evaluate the target volume, radiation source intensity, prescription dose and treatment time, to determine the cause of deviation according to the feedback results, ensuring that the afterloading treatment plan can be implemented efficiently quickly, and accurately in accordance with the clinical requirements.
2019 Vol. 28 (3): 105-112 [
Abstract
] (
29
)
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150
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113
The Application of Xenograft Materials in Patients with Minimally Invasive Tooth Extraction and Implant Restoration
JIANG Na, ZHAO Hui-juan
Objective:
The application effect of xenograft materials in patients with implant restoration after minimally invasive tooth extraction is explored.
Methods:
From February 2016 to December 2019, 80 patients with minimally invasive dental implants were treated in our hospital and selected as the research object. They were divided into the observation group and the control group based on to the random number table methods, and 40 patients in each group. The patients in the control group were sutured directly after minimally invasive tooth extraction. After the minimally invasive tooth extraction in the observation group, Bio-Oss Collagen was implanted into the alveolar fossa, which was covered with Bio-Gide absorbable biofilm. Changes in the height of the mastoid, the width and height of the crest crest, and the width of the lip between the two groups of patients immediately and 6 months after the tooth extraction were compared.
Results:
Changes of the alveolar ridge height and width in the observation group were less than those in the control group, and the difference was statistically significant（
t
=5.816, 3.997, and
P
=0.000）; the width of lip and tongue and the height of the interdental mastoid in the observation group. The amount of change was less than that in the control group, and the difference was statistically significant（
t
=7.384, 10.686, and
P
=0.000）.
Conclusion:
Bio-Oss Collagen and Bio-Gide absorbable biofilms have significant clinical effects on patients with minimally invasive tooth extraction and implant restoration, helping to maintain the stability of the alveolar ridge height and width, which is conducive to the creation of later dental implants in good conditions.
2019 Vol. 28 (3): 113-117 [
Abstract
] (
16
)
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104
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118
Heart Rate Extraction of Ballistocardiogram Based on Hilbert-Huang Transformation
CAO Xin-rong, GUO Hong, TANG Jin-tian
Objective:
Ballistocardiogram (BCG) is a kind of signal that reflects the movement of human body caused by the mechanical activity of cardiovascular system, especially during the heart contraction. Compared to other methods on assessing vascular healthy condition, the acquisition of BCG didn't need any direct contact with human body. This paper uses Hilbert-Huang transformation (HHT) to calculate the heart rate and detect the artifacts.
Methods:
HHT was a newly-developed method for non-linear data analysis, and ensemble empirical mode decomposition (EEMD) based HHT was a modified HHT method which used white noise to improve the analysis result. A device that could record BCG signal and ECG signal synchronously was built in our lab and 10 subjects' signals were collected and analyzed. EEMD based HHT was applied to BCG signal to calculate the heart rate. Heart rate calculated using ECG was used as a standard value to verify the result calculated from BCG. Besides, BCG was easily affected by the body movement, so we tried to use HHT to detect the artifacts in the BCG signal.
Results:
Our research showed that EEMD based HHT with a proper white noise level could be used to calculate the heart rate in BCG. Artifacts in the decomposition component were enhanced in the decomposition components of EEMD and became easier to detect than that in original BCG signal.
Conclusion:
Therefore, HHT could help to calculate the heart rate, enhance and detect artifacts caused by movements of human body in BCG signal.
2019 Vol. 28 (3): 118-124 [
Abstract
] (
21
)
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125
The Method of Fast on-site Detection and Real-time Release of Ammonia Nitrogen in Water
MA Xin-hua, OU Guo-rong
Objective:
This paper aims to establish a simple and practical method for the rapid detection of ammonia nitrogen in water on the spot, and to transmit the detection results to the Internet via GSM network, and to publish and update them in real time.
Methods:
Phenol salt colorimetry was used to measure the absorbance value of indigo phenol blue, the product of the reaction between ammonia nitrogen and phenol salt in water samples, using sodium nitrosoferricyanide sodium hydroxide as catalyst and a microphotoelectric colorimetric instrument developed by ourselves, or a simple visual colorimetric semi-quantitative method was used to measure the ammonia nitrogen content in water samples. Then, the general GSM wireless communication module built in the microphotoelectric colorimeter was used to realize the remote transmission of the test result data and the real-time update and release on the Internet.
Results:
The results of this method showed that the correlation of the method was significant, and the precision and accuracy were similar to the national standard Nessler's reagent spectrophotometry. The relative standard deviation is 4.4%, and the relative error is 2.7%. In 5-10 min, the detection of ammonia and nitrogen in single water sample can be completed on site, and the results can be released. For quantitative and semi-quantitative detection, the lowest detection concentrations are 0.05 mg/L and 0.2 mg/L, respectively, which are basically free from the interference of pH and common ions. In the coverage area of GSM network, the wireless transmission of data results was unobstructed and delayed, and the effect was satisfactory.
Conclusion:
The method is simple, rapid, practical and reliable, which is suitable for the field rapid determination of ammonia nitrogen in water, and the real-time remote transmission of the detection results. It provides a high-efficiency, low-cost and simple technical means for the field water quality monitoring and the rapid acquisition of water quality data.
2019 Vol. 28 (3): 125-131 [
Abstract
] (
21
)
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135
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Review
132
Research Progress on Lycopene in the Prevention and Treatment of Neurodegenerative Diseases
QU Ming-yue, QIU Hong-jie, HU Hong-fang
Lycopene is a natural pigment in tomato, watermelon, pomegranate, and other plants. It belongs to the carotenoid family. It has the biological function, it possess anti-oxidative properties, induces intercellular communication, and regulates cell proliferation. In recent years, a large number of studies have confirmed the active role of lycopene in the prevention and treatment of neurodegenerative diseases, and the mechanism involved includes inhibition of oxidative stress, maintenance of mitochondrial function, and modulation of apoptosis among others. In this review, the research reports on lycopene in the prevention and treatment of neurodegenerative diseases in recent years were summarized.
2019 Vol. 28 (3): 132-138 [
Abstract
] (
17
)
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147
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