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中国生物医学工程学会
北京玛格泰克科技发展有限公司
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2018 Vol. 27, No. 4
Published: 2018-12-01
Research papers
Research papers
139
Trichostatin A and Shear Stress in Regulating Endothelium Differentiation of Bone Marrow Mesenchymal Stem Cells
WEI Song, HUANG Yan, JIA Xiao-ling, GONG Xiang-hui, ZHEN Li-sha, FAN Yu-Bo
Differentiation of bone marrow mesenchymal stem cells (MSCs) into endothelial cells (EC) is characterized by the expression of specific endothelial marker genes. Mechanical stimulations play potential effects in EC oriented differentiation of MSCs. However, molecular mechanisms of endothelial differentiation from MSCs have not been defined.Histone acetylations play important roles in regulating gene expression. Histone acetylation status is maintained by histone acetyltransferase (HAT) and histone deacetylases (HDACs). Our previous work described that VEGF and laminar shear stress (SS) work together in determining EC oriented differentiation of MSC. Trichostatin A (TSA) is one of the lustone deacetylase inhibitor. In this study, we found that both TSA and SS could induce EC oriented differentiation of MSCs. And TSA combined with SS showed more powerful influence on the EC oriented differentiation of MSCs.
2018 Vol. 27 (4): 139-143 [
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144
Influence of Meniscal Attachments Placement on Articular Stress Deterioration
YAO Jie, NIU Wen-xin, Cheung Jason Tak-Man, ZHANG Ming, FAN Yu-bo
Meniscal attachments provide constraint for meniscus and contribute to knee stability. However, the influence of attachments placement on articular mechanical environment remains unclear. The present study aims to characterize the stress deterioration caused by abnormal attachment locations. Different placement of medial meniscal attachments were analyzed with a three-dimensional(3D) finite element (FE) model of knee joint. The articular stress distribution under compressive loadings indicates that abnormal placement of medial meniscal attachments could cause stress deterioration in meniscus and tibia plateau, which may increase the risk of OA. The influence of PMMA relocation was more severe than that of AMMA. The anterior displacement of both AMMA and PMMA could decrease the tibial contact area and therefore weakening the meniscal function of loading transmission. The present study provides an insight into the biomechanical character of meniscal attachments and may help improving the meniscal transplantation in the future.
2018 Vol. 27 (4): 144-150 [
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22
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151
Changes of Plantar Pressure Distribution Caused by Fatigue after Three Different Motions
FAN Xiao-ya, YANG Yang, PU Fang, YE Ying-hua, LI De-yu, FAN Yu-bo
Objective:
Foot injuries usually happen due to fatigue. Therefore,it is important to understand the changes of gait induced by foot fatigue. This paper aims to discuss the different changes of plantar pressure distribution (PPD) caused by fatigue after three different motions.
Materials and Methods:
The PPD of six healthy subjects were measured before and after speed steady running, shuttle running and speed agility running by the Footscan system. The peak force and contact time from ten plantar anatomical regions were calculated.
Results:
There was a significant difference in PPD between pre- and post-running. Furthermore, the changes of foot loading characteristics caused by fatigue in different motions were evidently distinct.
Discussion:
The possible reason may be the different fatigue degrees of muscles after different motions. It suggested that the effects of fatigue on gait in different motions must be considered to avoid sports injuries and different safeguard procedures should be taken in various motions to decrease the incidence of injuries induced by fatigue.
2018 Vol. 27 (4): 151-157 [
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25
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158
Silicon Nanowire-Based Methodology for Quantifying Single Cell Traction Force
NIU Yong-shan, YAN Ling, DAI Ming, FAN Yu-bo, LI Zhou
In this paper, we present a new method, a silicon-nanowire-array based technique for quantifying the mechanical behavior of single cells, representing three distinct groups: normal mammalian cells, benign cells (L929) and malignant cells (HeLa). By culturing the cells on top of NW arrays, the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires. The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing. Finite element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW. Our study is likely important for studying the mechanical properties of single cells and their migration characteristics, possibly providing a new cellular level diagnostic technique.
2018 Vol. 27 (4): 158-164 [
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21
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165
Hydrophilicity Evaluation of Collagen Based Scaffold Optimized by Chitin Fibres for Bone Tissue Engineering
LI Xiao-ming, FAN Yu-bo, FENG Qing-ling, CUI Fu-zhai
Chitin is a kind of seemly material to match PLLA for a scaffold, which may create an appropriate environment for the regeneration of tissues. In this study, we evaluated hydrophilicity of a new nano-hydroxyapatite/collagen/PLLA (nHACP) scaffold optimized by chitin fibres for bone tissue engineering. The results show that with the CF content increase, hydrophilicity of nHACP/CF increases, which reflects from the side that the addition of the chitin fibres can improve the cytocompatibility of the nHACP. Moreover, crosslink does not take significant influences on the material hydrophilicity. The results suggest that nHACP/CF with the crosslink should be a kind of potential appropriate scaffold for tissue engineering.
2018 Vol. 27 (4): 165-170 [
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41
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171
Long-term Prediction of Bone Density Distribution for Retained Intramedullary Nail
WANG Chao, WANG Li-zhen, FAN Yu-bo
Intramedullary nailing is a standard treatment for adult long bone fracture. Previous numerous animal, biomechanical and clinical studies have documented the short-term performance of the intramedullary nails; however, the long-term influence of the nails on the change of bone density distribution is still not fully understood. According to bone remodeling theory, a set of computational algorithms was implemented in the finite element model to predict the bone density distribution for retained intramedullary nail. The bone density was recorded to observe the progression of remodeling. The results show that the effect of intramedullary nail on the Gruen zone 4 and 5 of femur is small, while the effect on the Gruen zone 1, 2 and 6 is greater than other zones. This simulation indicates that intramedullary nail plays a significant role in the long-term bone density distribution after surgery.
2018 Vol. 27 (4): 171-177 [
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34
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178
Evaluation of a New Design to Improve the Flexibility of the Nucleus Standard Straight Array Cochlear Implant
Benjamin Kuan Chen, Sive Naidoo Lingamanaik, Roger La Brooy, Romesh Nagarajah
Cochlear implants can successfully provide auditory information for bilaterally profoundly deaf patients by electrically stimulating auditory nerve fibres via an electrode array, which is surgically implanted into the scala tympani of the cochlea. It is therefore important that the electrode array does not cause damage to the fine intracochlear structures during the process of insertion, as this can result in the loss of spiral ganglion cells, which are necessary for the implant to evoke auditory percepts. There is strong evidence that trauma and damage during insertion of electrode arrays into the human cochlea are related to the stiffness of the electrode array. Previous studies were conducted to experimentally determine the stiffness properties of electrode arrays using three-point flexural bending and buckling tests.In this paper, the design of nucleus straight electrode array is modified to give a greater flexibility to further reduce the risk of trauma to delicate structures of the cochlea during surgical insertion of the electrode array. This is achieved by reducing the cross-sectional area of the electrode array at selected positions over its length. Improvements in the flexibility of the new straight electrode array and the bending behavior at its tip have been demonstrated using finite element analysis. Loads applied to the tip of the electrode array at different angles with respect to the longitudinal axis of the electrode array showed that the modified design caused the tip to be more flexible and therefore better able to curl around the inner spiral of the scala tympani and thus less likely to penetrate the basilar membrane during insertion. Loads applied at other positions along the electrode array showed that bending occurred more readily using the modified design thereby reducing the friction and shear stresses at the contact interface between the electrode array and the delicate cochlea structures.
2018 Vol. 27 (4): 178-184 [
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