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	The format and skills of medical English Writing

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	中国生物医学工程学会

	北京玛格泰克科技发展有限公司

2019 Vol. 28, No. 2 Published: 2019-06-01

Research papers Review

Research papers

	47	The Effect of Neoadjuvant Chemotherapy Combined with Laparoscopic Surgery on the Prognosis of Advanced Gastric Cancer
		LIU Qi, YUAN Bo, DU Ying-lian
		*Objective:* To investigate the effect of neoadjuvant chemotherapy combined with laparoscopic surgery on the prognosis of advanced gastric cancer. *Methods:* From January 2014 to January 2016, 96 patients with advanced gastric cancer were selected from the general surgery department of the Fourth People's Hospital of Haikou. All patients underwent laparoscopic radical gastrectomy. According to the wishes of patients and their families, patients were divided into study group and control group, 48 cases in each group. The control group received laparoscopic gastrectomy, and the study group received laparoscopic gastrectomy after neoadjuvant chemotherapy. To analyze the curative effect and adverse reactions of the patients in the study group after chemotherapy; to compare the perioperative indexes and the incidence of postoperative complications of the two groups, and to compare the R0 resection rate of the two groups. The patients were followed up to find out the postoperative survival, and the 1-year, 2-year and 3-year survival rates of the two groups were compared. *Results:* All patients in the study group completed three courses of chemotherapy without interruption or stop. After chemotherapy, the objective response rate (ORR) was 45.83%, and the clinical benefit rate (CBR) was 93.75%. Most of the adverse reactions of chemotherapy were grade I-II, and the symptoms were relieved after the symptomatic treatment, and the patients could tolerate it. There was no significant difference between the two groups (P>0.05). The main postoperative complications of the two groups were incision infection, lung infection, abdominal infection, intestinal obstruction, anastomotic leakage, lower extremity deep vein thrombosis, and gastric emptying disorder. The incidence of postoperative complications in the study group was 20.83%, no significant difference compared with 25.00% in the control group (P>0.05). The removal rate of R0 in the study group was 81.25%, significantly higher than that in the control group (45.83%) (P<0.05). The 1-year, 2-year and 3-year survival rates of the study group were higher than those of the control group, the difference was statistically significant (P<0.05). *Conclusion:* Neoadjuvant chemotherapy before laparoscopic resection of advanced gastric cancer can improve the resection rate of R0 and the survival rate of the patients, which has no significant effect on the perioperative indexes and complications of laparoscopic surgery.
		2019 Vol. 28 (2): 47-56 [Abstract] ( 24 ) HTML (1 KB) PDF (7312 KB) ( 7 )

	57	Effects of Preemptive Analgesia with Flurbiprofen Axetil Injection on Analgesia, Inflammatory Response, Stress Response and Immune Response in Patients Undergoing Thoracoscopic Lobectomy
		LI Na, WANG Fen-li, ZOU Ming-shan
		*Objective:* To investigate the effect of preemptive analgesia with flurbiprofen axetil injection on the analgesic effect, inflammatory response, stress response and immune response in patients undergoing thoracoscopic lobectomy. *Methods:* 92 patients with early non-small cell lung cancer who underwent thoracoscopic lobectomy from January 2016 to March 2018 in our hospital were divided into observation group and control group according to the method of random digital table, 46 cases in each group. The control group was given routine perioperative analgesia, the observation group was given advanced analgesia mode, and the visual simulation scoring method (visual) was used to observe the patients in the two groups at 4, 12, 24 and 48 h after operation The results showed that the level of inflammation factor, stress response factor and immune response were significantly higher than that of before operation (T0), when anesthesia woke up (T1), 12 hours after operation (T2), 24 h after operation (T3) and 48 h after operation (T4). *Results:* (1) The VAS score of the observation group was significantly lower than that of the control group (P<0.05) at 4, 12, 24 and 48 h after operation; (2) The levels of IL-6, IL-10, SP-A and TNF-α in the two groups were significantly lower than that of the control group (P<0.05) The level of factor-α, TNF-α) was higher than that of to time point, and showed an upward trend; the level of IL-6, IL-10, TNF-α, SP-A decreased gradually at T3, T4 time points, the level of IL-6, TNF - α, SP-A in T1, T2, T3, T4 time points in the observation group was lower than that of the control group, and the level of IL-10 was higher than that of the control group (P<0.05); (3) Compared with T0 time point, the epinephrine (EPIPH) at T1, T2, T3, T4 time points in the two groups The levels of rine, e, noradrenaline, NE and cortisol in the observation group increased first and then decreased; the levels of E, NE and cor in the observation group were lower than those in the control group at T1, T2, T3 and T4 time points (P<0.05); and (4) Compared with T0 time point, the serum IgG, IgM and IgA levels in the two groups decreased gradually at T1, T2, T3 and T4 time points, but the observation group The levels of IgG, IgM and IgA in serum of group A were higher than those of group B(P<0.05). *Conclusion:* Preemptive analgesia with flurbiprofen axetil injection can significantly improve the postoperative pain, reduce the level of inflammation, reduce the stress response and increase the level of immune response.
		2019 Vol. 28 (2): 57-65 [Abstract] ( 19 ) HTML (1 KB) PDF (6408 KB) ( 109 )

	66	Expression of Serum hs-CRP and Lp-PLA2 in Arrhythmia Patients and its Significance
		CONG Xiu-feng
		*Objective:* The purpose of this study is to examine the expression of serum high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with arrhythmia and its significance. *Methods:* We selected 136 arrhythmia patients (observation group) who were treated at our hospital from February 2016 to March 2018. Among these patients, 50 had premature ventricular contractions, 42 had atrial fibrillation, 24 had atrial flutter, and 20 had ventricular tachycardia. Simultaneously, we selected 120 healthy volunteers as the control group. We measured serum levels of hs-CRP and Lp-PLA2 in these subjects. *Results:* The levels of Lp-PLA2 and hs-CRP of the observation group were 210.06±30.46 pg/mL and 13.54±3.16, respectively, which were significantly higher than those of the control group (P<0.05). The serum levels of Lp-PLA2 and hs-CRP of patients with atrial flutter were 260.87±32.24 and 19.84±5.10 pg/mL, respectively, which were significantly higher than those of patients with premature ventricular contractions, atrial fibrillation, and ventricular tachycardia (P<0.05). Serum levels of Lp-PLA2 and hs-CRP were positively correlated (r=0.413, P<0.05). *Conclusion:* Serum levels of hs-CRP and Lp-PLA2 in arrhythmia patients were significantly elevated and showed some association with the type of arrhythmia.
		2019 Vol. 28 (2): 66-71 [Abstract] ( 25 ) HTML (1 KB) PDF (4341 KB) ( 89 )

	72	Effect of Laparoscopic Peritoneal Dialysis Catheterization on Patients with Stress Response
		ZHENG Jie, LAI Jian, LI Xiao-sheng, CAO Feng, TANG Xian-hu
		*Objective:* To observe the effect of laparoscopic peritoneal dialysis (PD) catheterization on stress response. *Methods:* The clinical data of 60 patients with stage 5 chronic kidney disease treated in our hospital from March 2016 to October 2019 were analyzed retrospectively. According to the different operation methods, they were divided into two groups. 34 patients who received open PD catheterization were included in the control group, and 26 patients who received laparoscopic PD catheterization were used as the observation group. The intraoperative indexes, C-reactive protein (CRP), procalcitonin (PCT) levels and complications were compared between the two groups. *Results:* In the observation group, the bleeding volume was (16.27±4.13) mL, less than that in the control group, the operation time was (48.93±10.16) min, shorter than that in the control group, the incidence of catheter displacement was lower than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the levels of CRP and PCT between the two groups (P>0.05); the levels of CRP (47.25±16.91) mg/L and PCT (0.07±0.01) μ g/L in the observation group were lower than those in the control group (P<0.05). *Conclusion:* Laparoscopic PD catheterization in the treatment of end-stage renal disease has the advantages of small trauma, mild stress response and quick postoperative recovery, and it can reduce the occurrence of catheter displacement and the risk of PD catheterization.
		2019 Vol. 28 (2): 72-76 [Abstract] ( 27 ) HTML (1 KB) PDF (3329 KB) ( 115 )

Review

	77	Research Progress on Adaptive Statistical Iterative Reconstruction and its Applications
		GAO Yan-shan
		CT has been widely used for clinical diagnosis since it was introduced in China in the last century because of its superior effect on 2D anatomical observation capacity and higher resolution than other techniques. With the development of CT technology in recent years, 128 rows, 256 rows, or higher resolution CT is available, but the negative effects of radiation dose have attracted attention. How to reduce the dose of CT and the radiation to patients and medical staff under the premise of ensuring the image quality is a hot topic for medical research. This paper reviews the effective methods of CT radiation by iterative reconstruction technology, in order to provide a reference for reducing the dose of CT and the radiation dose of patients and medical staff.
		2019 Vol. 28 (2): 77-81 [Abstract] ( 25 ) HTML (1 KB) PDF (4182 KB) ( 146 )

	82	Research Progress on the Application of Three-dimensional CT Imaging Technology in Oral and Maxillofacial Region and Radiation Protection
		ZHANG Jian-quan
		The anatomic relationship of oral and maxillofacial region is very complex, due to the large number of sinuses, cavities and spaces, and also closely related to the brain. The diagnosis of oral and maxillofacial lesions usually depends on the imaging examination. The conventional imaging methods are common CT and X-ray plain films. In recent years, with the rapid development of medical science and technology, more intuitive and vivid three-dimensional images have been applied in the diagnosis and treatment of oral and maxillofacial diseases. Therefore, CT three-dimensional imaging technology has been widely used in clinical practice. This paper reviews this topic.
		2019 Vol. 28 (2): 82-86 [Abstract] ( 21 ) HTML (1 KB) PDF (3915 KB) ( 118 )

	87	The Application of Ultrasound in Airway Management
		ZHANG Yan-jun, ZHANG Jin-zhu
		With the continuous improvement and progress of ultrasound technology in recent years, its application in the field of anesthesia is becoming more and more universal. Airway management is an important part of perioperative medicine. With the progress of perioperative safety, accuracy, comfort and visualization management concept, the application of ultrasound technology in perioperative airway management is gradually increasing. This paper reviews the application of ultrasound on the evaluation of difficult airway, the prediction of the type of tracheal tube, the determination of the position and depth of the tracheal tube, the prediction of wheezing after extubation, the evaluation of the position of the laryngeal mask, the localization of the cricothyroid membrane, the percutaneous dilatation of the tracheotomy, the evaluation of the patients with obstructive sleep apnea, the measurement of gastric contents and the evaluation of the invasion of the trachea by thyroid cancer The application of this method provides some references.
		2019 Vol. 28 (2): 87-92 [Abstract] ( 24 ) HTML (1 KB) PDF (3974 KB) ( 88 )

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