Effects of Preemptive Analgesia with Flurbiprofen Axetil Injection on Analgesia, Inflammatory Response, Stress Response and Immune Response in Patients Undergoing Thoracoscopic Lobectomy

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (6408 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the effect of preemptive analgesia with flurbiprofen axetil injection on the analgesic effect, inflammatory response, stress response and immune response in patients undergoing thoracoscopic lobectomy. Methods: 92 patients with early non-small cell lung cancer who underwent thoracoscopic lobectomy from January 2016 to March 2018 in our hospital were divided into observation group and control group according to the method of random digital table, 46 cases in each group. The control group was given routine perioperative analgesia, the observation group was given advanced analgesia mode, and the visual simulation scoring method (visual) was used to observe the patients in the two groups at 4, 12, 24 and 48 h after operation The results showed that the level of inflammation factor, stress response factor and immune response were significantly higher than that of before operation (T0), when anesthesia woke up (T1), 12 hours after operation (T2), 24 h after operation (T3) and 48 h after operation (T4). Results: (1) The VAS score of the observation group was significantly lower than that of the control group (P<0.05) at 4, 12, 24 and 48 h after operation; (2) The levels of IL-6, IL-10, SP-A and TNF-α in the two groups were significantly lower than that of the control group (P<0.05) The level of factor-α, TNF-α) was higher than that of to time point, and showed an upward trend; the level of IL-6, IL-10, TNF-α, SP-A decreased gradually at T3, T4 time points, the level of IL-6, TNF - α, SP-A in T1, T2, T3, T4 time points in the observation group was lower than that of the control group, and the level of IL-10 was higher than that of the control group (P<0.05); (3) Compared with T0 time point, the epinephrine (EPIPH) at T1, T2, T3, T4 time points in the two groups The levels of rine, e, noradrenaline, NE and cortisol in the observation group increased first and then decreased; the levels of E, NE and cor in the observation group were lower than those in the control group at T1, T2, T3 and T4 time points (P<0.05); and (4) Compared with T0 time point, the serum IgG, IgM and IgA levels in the two groups decreased gradually at T1, T2, T3 and T4 time points, but the observation group The levels of IgG, IgM and IgA in serum of group A were higher than those of group B(P<0.05). Conclusion: Preemptive analgesia with flurbiprofen axetil injection can significantly improve the postoperative pain, reduce the level of inflammation, reduce the stress response and increase the level of immune response.

Key words： flurbiprofen axetil injection preemptive analgesia thoracoscopic lobectomy analgesic effect immune response

Received: 20 April 2019

Corresponding Authors: ZOU Ming-shan. E-mail: mingszh@gmail.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Na
	WANG Fen-li
	ZOU Ming-shan

Cite this article:

LI Na,WANG Fen-li,ZOU Ming-shan. Effects of Preemptive Analgesia with Flurbiprofen Axetil Injection on Analgesia, Inflammatory Response, Stress Response and Immune Response in Patients Undergoing Thoracoscopic Lobectomy[J]. Chinese Journal of Biomedical Engineering, 2019, 28(2): 57-65.

URL:

http://manu32.magtech.com.cn/Jwk_zgswyx_en/EN/ OR http://manu32.magtech.com.cn/Jwk_zgswyx_en/EN/Y2019/V28/I2/57

[1] Zhang Lin, Zhao Qi, Wang Xin, et al.The effect of flurbiprofen axetil combined with dizosin on the prevention of postoperative hyperalgesia in remifentanil patients[J]. Chinese Journal of Anesthesiology, 2016,36(4):392-395.
[2] Zhu Xiaochang, Zhi Lianjun, Wang Shuang, et al.Prevention of hyperalgesia after remifentanil anesthesia with flurbiprofen axetil[J]. Journal of Clinical Anesthesiology, 2016,32(9):889-891.
[3] Chen H, Luo A.Safety and efficacy study of the cyclooxygenase-2 inhibitor parecoxib sodium applied for postoperative analgesia after endo-nasal operation[J]. Pain Pract, 2016, 16(4):467-472.
[4] Gao Kai, Wang Xiaofei, Wang Miao.Observation on the effect and adverse reactions of flurbiprofen axetil in advanced analgesia of orthopaedic surgery[J]. Shaanxi Medical Journal, 2016,45(1):78-80.
[5] Qiu Xiaojuan, Chen Kai, Hu bin, et al. Research progress in the application of parixib sodium in postoperative analgesia[J]. Progress in Modern Biomedicine, 2018,18(2):385-388.
[6] Han Youling, Liu Gongjian.Evaluation of the effect of dexmedetomidine in patient controlled intravenous analgesia after sufentanil combined with flurbiprofen axetil[J]. Journal of Practical Clinical Medicine, 2016,20(17):160-162.
[7] Li X, Yu L, Yang J, et al.Multimodal analgesia with ropivacaine wound infiltration and intravenous flurbiprofen axetil provides enhanced analgesic effects after radical thyroidectomy: a randomized controlled trial[J]. BMC Anesthesiol, 2019,19(1): 167.
[8] Ye H, Lian X, Chen R, et al.Intraoperative administration of intravenous flurbiprofen axetil with nalbuphine reduces postoperative pain after orbital decompression: a single-center, prospective randomized controlled trial[J]. J Pain Res,2019,12: 659-665.
[9] Oh SK, Kwon WK, Park S, et al. Comparison of operating conditions, postoperative pain and recovery,overall satisfaction of surgeons with deep vs. no neuromuscular blockade for spinal surgery under general anesthesia: a prospective randomized controlled trial[J]. J Clin Med, 2019,8(4): pii: E498.
[10] Paterson HM.Continuous intravenous lidocaine infusion for postoperative pain and recovery in adults[J]. Tech Coloproctol, 2019,23(1):69-71.
[11] Li X, Zhou M, Xia Q, et al.Parecoxib sodium reduces the need for opioids after tonsillectomy in children: a double-blind placebo-controlled randomized clinical trial[J]. Can J Anaesth, 2016,63(3):268-274.
[12] Ding Xuefei, Luan Yang, Lu Shengming, et al.The effect of combined application of peripheral nerve block anesthesia and flurbiprofen axetil multimodal analgesia in prostate biopsy[J]. Chinese Journal of surgery, 2019,57(6):428-433.
[13] Lv N, Kong Y, Mu L, et al.Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial[J]. Eur Radiol,2016,26(10): 3492-3499.
[14] Zhang Xiaolin, Chai Xiaoqing, Wang Di.Lung protective effect of flurbiprofen axetil and its combined protective mechanical ventilation on patients undergoing thoracotomy[J]. Chinese Journal of Anesthesiology,2016,36(3):272-276.
[15] Aziz RS, Siddiqua A, Shahzad M, et al.Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α, NF-B, and COX-2 levels, and upregulation of TFF-2 levels[J]. Biomed Pharmacother,2019,110:554-560.
[16] Ghassib I, Chen Z, Zhu J, et al.Use of IL-1 β, IL-6, TNF-α, and MMP-8 biomarkers to distinguish peri-implant diseases: A systematic review and meta-analysis[J]. Clin Implant Dent Relat Res, 2019,21(1):190-207.
[17] Zhuang Q, Bian Y, Wang W, et al.Efficacy and safety of postoperative intravenous parecoxib sodium followed by oral celecoxib (PIPFORCE) post-total knee arthroplasty in patients with osteoarthritis: a study protocol for a multicentre, double-blind, parallel-group trial[J]. BMJ Open, 2016,6(9): e011732.
[18] Bamgbade OA, Oluwole O, Khaw RR.Perioperative analgesia for fast-track laparoscopic bariatric surgery[J]. Obes Surg, 2017,27(7): 1828-1834.
[19] Song Yun, min Su, Cheng Bo, et al. Comparison of the analgesic effect of parecoxib sodium and flurbiprofen axetil after thyroidectomy and their effects on hemodynamics and inflammatory cytokines[J]. Progress in Modern Biomedicine, 2017,17(13): 2459-2462.
[20] Lu J, Chen G, Zhou H, et al.Effect of parecoxib sodium pretreatment combined with dexmedetomidine on early postoperative cognitive dysfunction in elderly patients after shoulder arthroscopy: a randomized double blinded controlled trial[J]. J Clin Anesth, 2017,41:30-34.
[21] Gao Yu.The effect of multi-mode analgesia with flurbiprofen axetil on cellular immune function in patients undergoing radical gastrectomy[J]. Journal of Qiqihar Medical College, 2016,37(7): 906-907.
[22] Mu DL, Zhang DZ, Wang DX, et al.Parecoxib supplementation to morphine analgesia decreases incidence of delirium in elderly patients after hip or knee replacement surgery: a randomized controlled trial[J]. Anesth Analg,2017,124(6): 1992-2000.
[23] Zou Liangwang, Zhao Xiyue, Qiu Enyi, et al.Meta analysis of postoperative analgesic effect and adverse drug reactions of flurbiprofen axetil and tramadol[J]. Journal of Wenzhou Medical University, 2017,47(3):206-210.
[24] Zhou Hong, pod Weidong, Qiao Xiaofei, et al. Application of multimodal prophylactic analgesia in perioperative period of patients with partial hepatectomy of liver cancer[J]. Chinese Journal of Surgery, 2017,55(2):141-145.
[25] Castro-Alves LJ, Kendall MC.Confounding and adjustment factors in the effect of intravenous parecoxib on shoulder pain after thoracotomy[J]. J Cardiothorac Vasc Anesth,2018,32(3):e55.