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中国生物医学工程学会
北京玛格泰克科技发展有限公司
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2016 Vol. 25, No. 3
Published: 2016-09-01
Research papers
Research papers
93
Registration-based Automatic 3D Segmentation of Cardiac CT Images
LI Li-hua, YANG Rong-qian, HUANG Yue-shan, WU Xiao-ming
Segmenting whole heart from cardiac computed tomography (CT) images can provide an important basis for the evaluation of cardiac function and help improve the accuracy of clinical diagnosis. Manual segmentation is the most accurate method for cardiac segmentation. But it is time consuming and not sufficiently reproducible. However, clinicians still rely on this method in practical applications. So a fully automatic method is needed to improve the segmentation efficiency. This paper proposes a registration-based automatic approach for three-dimensional (3D) segmentation of cardiac CT images. The proposed method utilizes the similarity of cardiac CT images between different individuals, and uses registration to achieve the segmentation. Affine transformation is firstly implemented to achieve global coarse registration. Then, cubic B-splines are used to refine the local details in locally accurate registration. Mutual information (Ml) is used as the similarity measure, and adaptive stochastic gradient descent (ASGD) as the optimization algorithm. Our method is applied to the dual-source cardiac CT images to segment whole heart. Experimental results show that the proposed method can automatically segment whole heart from cardiac CT images.
2016 Vol. 25 (3): 93-99 [
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23
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100
Design of a Web-based Medical Equipment Management System for Clinical Engineering
LIU Sheng-lin, ZHANG Qiang, WU Han-xi, ZHANG Xu-tian, WANG Guo-hong
Objective:
Medical equipment safety in clinical use has been an increasingly concerned issue in China. This paper aims to design and implement a web-based medical equipment maintenance system to be used at clinical engineering department, orienting to the improvement of quality and efficiency of technology service so as to meet the 2010 regulations homologated with China's Ministry of Health.
Methods:
The system adopted three-layer structure based on B/S mode with oracle database and ASP.NET development technologies. Based on risk management and inclusion criteria for maintenance, the software system modules consist of hospital equipment inventory management, personnel information management, breakdown maintenance, preventive maintenance (PM) and analysis graphical representations.
Results:
An user friendly web interface was provided for easy and secure access to the system. Medical equipment management activities from log-in to acceptance test to maintenance services were implemented.
Conclusion
The application of this system has achieved benefits for the risk management of medical equipment.
2016 Vol. 25 (3): 100-106 [
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24
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107
D Shape-based Fluorescence Molecular Tomography Through Hybrid Genetic Algorithm Based Optimization
WANG Dai-fa, WANG Ling, FAN Yu-bo, LI De-yu
Fluorescence molecular tomography (FMT) aims at tomographically resolving the fluorescent targets deeply inside small animal based on transmission boundary measurements. The image reconstruction of FMT is known to be highly ill-posed, due to the highly scattering nature of biological tissue. Hence, prior information is usually required for successful reconstruction. In this paper, a novel reconstruction method incorporating shape priors is proposed for 2D FMT. The fluorescent targets were assumed of round shape, which was practically appropriate for approximating various shapes inside diffusive medium. Compared to the traditional pixel based reconstruction, the number of unknowns was greatly reduced to a few control parameters of round shapes. A hybrid genetic algorithm was proposed to recover the shape parameters. The numerical experiments showed that the proposed method significantly improves the imaging accuracy, offering clearer target boundaries and better resolution. Comparison results also demonstrated that the hybridization of genetic algorithm and Newton-type search was pivotal and important for robustly finding the globally optimal shape parameters.
2016 Vol. 25 (3): 107-113 [
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28
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114
A Community Health Service Architecture Based on the Internet of Things on Health-Care
WU Zhao, LIU Lei-hong, HUANG Yue-shan, WU Xiao-ming
In order to assure a real-time medical care for the elders who live alone or have a chronic disease and also to improve the responsiveness and quality of the community hospital, a community health service architecture was designed according to the Internet of Things on Health-Care. The users' body physiological and sports information can be collected intelligently by the health sensors at home and then the health information can be transmitted to the community health-care center through networks after information processing. The community doctors can provide a medical service on kinds of video, voice or email according to the users' process notes, test data and symptoms. Of course, doctors also can communicate and share their opinions with other specialist who is online. The key technology of this system is Internet of Things on Health-Care, which system can get users' health information actively and then make out intelligent decisions promptly and finally provide a more personal health service.
2016 Vol. 25 (3): 114-120 [
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19
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121
Motif Discovery and Phylogenetic Analysis of Hepatitis B Virus Sequences
ZHANG Qi, ZHANG Jun-peng, GAO Jian-mei, HE Jian-feng, YAN Xin-min, MA Lei, LI Jiu-yong
Hepatitis B virus (HBV) infection is a severe global health problem. In recent years, mutations as an essential element in the HBV evolution have been extensively studied. However, the study of the conserved sequence for the evolution of HBV is still in its infancy. In this paper, we applied MEME (multiple EM for motif elicitation) algorithm for motif discovery and proposed a new metric CI (conserved index) to make phylogenetic analysis of HBV sequences. Our results indicate that MEME can efficiently discover multiple motifs from HBV sequences and the new measurement CI for the conservative of sequences can effectively help us to build the phylogenetic tree. Thus, we can get evolutionary relationship of HBV sequence through the phylogenetic tree.
2016 Vol. 25 (3): 121-126 [
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22
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127
Increased Transendothelial Cells Permeability Induced by Oxidized Lipoprotein(a) Relates to Reactive Oxygen Species Generation and Desmogleins Expression
WANG Zuo, YANG Jian, ZHANG Xiao-lei, MA Xiao-feng, WANG Ren, ZENG Jun-fa, WEI Deng-heng, ZHANG Kai, LI Shuang, LIN Xiao-long, ZHAO Yue, JIANG Zhi-sheng
Objective:
This paper aims at measurement enhanced effect of oxidized lipoprotien(a) [oxLp(a)] on permeability of monolayer endothelial cells and relationship with reactive oxygen species(ROS) generation and desmogleins(DSGs) expression.
Methods
and
Results:
Transendothelial permeability was assayed by transwell and reactive oxygen species(ROS) was determined by DCFH-DA staining. RT-PCR was carried out to determine DSGl and DSC2 expression in mRNA, respectively. Transendothelial permeability was enhanced by oxLP(a) dose and time dependently. The most marked effect appeared at a concentration of 100 mg/L, Transendothelial permeability reached the maximum value after 2 h of FITC-dextran addition, and then gradually decreased after 4 h. oxLp(a) induces the generation of cellular reactive oxygen species (ROS), and this effect could be inhibited by superoxide dismutase(SOD). Incubation of HUVECs with oxLp(a) resulted in a dose and time-dependent down-regulation of DSGl and DSC2 expression at transcriptional level.
Conclusion
Permeability of monolayer endothelial cells was enhanced by oxLp(a) which is related to up-regulating ROS formation and down-regulating desmogleins expression.
2016 Vol. 25 (3): 127-133 [
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134
The Analysis of Effective Radiation Dose during PET/CT Examination
ZHANG Hong-yu, LI Ying-xin
Objective:
In order to reduce the effective dose level of the patients to explore the best scanning conditions, various factors affecting the level of PET/CT examination were analyzed.
Methods:
The effective doses of CT and pet were calculated respectively during PET/CT examination, Scanning parameters of CT and PET were optimized to reduce the effective dose of patients to a minimum while maintaining the image quality.
Results:
The tube voltage and tube current of CT, the injection dose during PET examination can affect the effective dose of the patients significantly.
Conclusion
According to different types of patients and diseases to develop personalized scanning program, the effective dose level of the patients can be significantly reduced.
2016 Vol. 25 (3): 134-138 [
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24
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