|
|
|
| Expression of bFGF and TGF-β in the Transversalis Fascia of Female Dogs with Inguinal Hernia |
| YIN Yu-hu |
| Xuanwei Hot Water Town Health Center,Yunnan Xuanwei 655415, China |
|
|
|
|
Abstract Objective: To investigate the expression of basic fibroblast growth factor (bFGF) and transforming growth factor β(TGF-β) in the transversalis fascia of female dogs with inguinal hernia. Methods: A total of 20 female dogs with inguinal hernia were selected as the research subjects, which were divided into two groups: the observation group (direct inguinal hernia female dogs, n=10) and the control group (indirect inguinal hernia female dogs, n=10). Immunohistochemistry was used to detect the expression of bFGF and TGF-β in the fascia transversalis. Results: The results showed that(1) The expression of bFGF and TGF-β was found to be positively linked with the speed of adhesion. The expression of bFGF and TGF-β significantly increased with the increase in adhesion speed; DAB staining revealed the presence of bFGF and TGF-β, with TGF-β showing diffuse or localized staining in the observation group. In contrast, the control group exhibited diffuse staining. In both the control group and the observation group, the bFGF exhibited either diffuse light staining or localized staining. (2)There was no statistically significant difference in bFGF levels between the observation group and the control group(P>0.05). The difference in TGF-β levels between the observation group and the control group was statistically significant (P<0.05). Conclusion: bFGF can be used to regulate the metabolism and synthesis of collagen in the body, thereby gradually changing the tensile strength of the transversalis fascia, which can have a significant impact on the occurrence and progression of inguinal hernia.
|
|
Received: 15 January 2023
|
|
|
|
Corresponding Authors:
YIN Yu-hu. E-mail: 2210347010@qq.com
|
|
|
|
[1] Cuzzocrea S, Esposito E, Paterniti I.Role of basic fibroblast growth factor in cancer: Biological activity, targeted therapies[J]. Prognostic Value Cells, 2023,12(7):1002.
[2] Frangogiannis NG.Transforming growth factor-β in myocardial disease[J]. Nat Rev Cardiol, 2022,19(7):435-455.
[3] Podolsky D, Novitsky Y.Robotic inguinal hernia repair[J]. Surg Clin North Am, 2020,100(2):409-415.
[4] Ahmed I, Ramsay G, Scott NW.Open versus laparoscopic repair of inguinal hernia: an overview of systematic reviews of randomised controlled trials[J]. Surg Endosc, 2022,36(7):4685-4700.
[5] Saccente-Kennedy B, Ambler G.The use of basic fibroblast growth factor to improve vocal function: A systematic review and meta-analysis[J]. Clin Otolaryngol, 2023,48(5):725-733.
[6] Christian JL, Hill CS.Transforming growth factor-β family biology: From basic mechanisms to roles in development and disease[J]. Dev Dyn, 2022,251(1):6-9.
[7] Shi L, Zhu Y, Ai D.Yes-associated protein targets the transforming growth factor β pathway to mediate high-fat/high-sucrose diet-induced arterial stiffness[J]. Circ Res, 2022,130(6):851-867.
[8] Song JH, Oh SY, Jo SA.Basic fibroblast growth factor induces cholinergic differentiation of tonsil-derived mesenchymal stem cells[J]. Tissue Eng Regen Med, 2022,19(5):1063-1075.
[9] Wiese M, Zarras K, Meyer HJ.Leistenhernienoperationen-immer ambulant[Inguinal hernia operations-Always outpatient][J]. Chirurgie (Heidelb), 2023,94(3):230-236.
[10] Lobe TE, Bianco FM.Adolescent inguinal hernia repair: a review of the literature and recommendations for selective management[J]. Hernia, 2022,26(3):831-837. |
| [1] |
Yin Shunjie, Chen Kai, Xue Kaiqing, Yao Dezhong, Xu Peng, Zhang Tao. A Review of Brain Network Research Methods Based on Canonical Correlation Analysis[J]. Chinese Journal of Biomedical Engineering, 2024, 43(2): 240-251. |
| [2] |
Wang Ruru, Zhou Xiaoqing, Zhao Yuhui, Liu Xu, Liu Zhipeng, Wang Xin, Yin Tao. Effects of Isoflurane Anesthesia on Spontaneous and TUS/TMAS Induced Electromyography in Mice[J]. Chinese Journal of Biomedical Engineering, 2024, 43(1): 10-17. |
|
|
|
|
