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| Improvement of MDA and SOD Expression and Optic Neuroprotection in Glaucoma Mice by Travoprost and β-Blocker |
| LIU Hai-hua, LIN Yi-long, ZHONG Jun-mu, LIU Jian-qiang |
| Longyan First Affiliated Hospital of Fujian Medical University, Fujian Longyan364000, China |
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Abstract Objective: The goal of this study was to see if travoprost and β -blockers improved MDA and SOD expression as well as neuroprotection in glaucoma mice. Methods: One hundred healthy SPF SD rats were randomly allocated into five groups: travoprost and β -blocker group, travoprost group, β -blocker group, model group and blank group, with 20 rats in each group. We created a glaucoma mouse model in which the blank group and the model group received the same volume of saline, the β -blocker group received β -blocker, the travoprost group received travoprost, and the travo Prost and β -blocker groups received travo Prost and β receptor blockers. Retinal cell apoptosis level, intraocular pressure level, MDA and SOD levels were measured after drug administration. Results: The results showed that the levels of intraocular pressure, the apoptosis rate of optic nerve, SOD and MDA of retina in travoprost and β -blocker group, travoprost group, β -blocker group and model group were greater than those in blank group(P< ; 0.05). In comparison to the model group, the intraocular pressure level, optic nerve apoptosis rate, and retinal MDA level in the travoprost and β -blocker group continued to fall, while the retinal SOD level was considerably elevated(P< ; 0.05). The continuous application of travoprost and β -blocker resulted in a constant drop in intraocular pressure, optic nerve apoptosis rate and MDA level in the retina, whereas the SOD level was dramatically elevated(P< ; 0.05). Conclusion: In glaucoma mice, travoprost in combination with a β -blocker can greatly increase MDA expression, SOD and neuroprotection.;
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Received: 20 February 2023
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Corresponding Authors:
LIU Hai-hua. E-mail: 419919241@qq.com
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