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| Comparison of Heart Rate Variability between Normoxia and Hypobaric Hypoxia Exposure |
| Yuanyuan Liu1, Zhengtao Cao2*, Mengsun Yu2, Jun Yang2, Binhua Wang3, Yingying Ma4 |
1. Institute of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan Shandong 250061, China;
2. Air Force Medical Center, PLA, Beijing 100142, China;
3. Medical Big Data Research Center, Chinese PLA General Hospital, Beijing 100853, China;
4. Department of Medical Engineering Management, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan Shandong 250021, China |
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Abstract This study aimed to use the sample entropy (SampEn) method to compare the difference between normoxia and hypobaric hypoxia exposure in heart rate variability. Eight healthy male volunteers were included in this research. For each subject, electrocardiography and finger pulse signal were recorded to obtain the heart rate time series. The SpO2 signal was collected at the same time. In normoxia or hypobaric hypoxia 4300 m section, the segment of RR time series from the second 5 min episode (from the 6th to the 10th min) was chosen for the SampEn calculation. The differences between normoxia and hypobaric hypoxia states were analyzed. Results showed that a significant difference exists in SampEn between two states (normoxia 0.54±0.05 vs hypobaric hypoxia 4300 m exposure 0.46±0.05), indicating the regulatory mechanisms of autonomic nervous system from a nonlinear perspective.
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