Home
About Journal
Editorial Board
Instruction
Subscribe
Messages Board
Contact Us
Quick Search
Office Online
Online Submission
Manuscript Tracking
Peer Review
Editor-in-Chief
Office Work
Current Issue
Accepted
Current Issue
Archive
Adv Search
Read Articles
Download Articles
Email Alert
Download
The format and skills of medical English Writing
More>>
Links
中国生物医学工程学会
北京玛格泰克科技发展有限公司
More>>
2018 Vol. 27, No. 2
Published: 2018-06-01
Research papers
Research papers
47
The Relationship Between Gene Mutation and Pathological Type of Lung Cancer
PANG Feng-rui, QU Fang, WU Bin, ZHA Wen-ting, LV Yuan
Objective:
To investigate the relationship between gene mutation and pathological type of lung cancer, inspect and verify the consistency between homologous genes mutation in various pathologic type.
Methods:
Combined with the COSMIC and UniProt database, we obtained the reported overall big-sample mutation data of lung cancer and the protein sequences of the top 20 mutated genes, respectively. Analyze the data and cluster the protein sequences and then deduce the homologous gene. Ultimately, analyze the mutations of different pathological types of homologous genes.
Results:
TP53 (32.32%) has the highest mutation rate in lung cancer, followed by EGFR (29.12%). The copy number variability (CNV) of genes: KRAS, LRP1B, CDKN2A, KMT2C, FAT1, PIK3CA, RB1, ERBB4, GRIN2A and KDR between each pathological type is statically significant (
P
<0.05). The gene differential expression rate between adenocarcinoma and squamous carcinoma of gene TP53, KRAS, LRP1B, CDKN2A, STK11, FAT4, KMT2D, NFE2L2, KEAP1, PIK3CA, RB1, ERBB4, SMARCA4 and KDR are statistically significant (
P
<0.05). The similarity of the protein sequence of EGFR and ERBB4 can reach 93%, and FAT4 and FAT1 are 81%. For small cell carcinoma, there's no difference in CNV between the two groups of homologous genes, and no difference between FAT4 and FAT1 in adenocarcinoma.
Conclusion:
The CNV and gene expression of lung cancer-associated genes are relevant to pathologic types. GFR and ERBB4 are homologous, FAT4 and FAT1 are also among the top 20 mutation genes. Additionally, there's no difference in CNV between the two groups of small cell carcinoma, which is the same between FAT4 and FAT1 in adenocarcinoma.
2018 Vol. 27 (2): 47-56 [
Abstract
] (
60
)
HTML
(1 KB)
PDF
(5666 KB) (
101
)
57
In vivo
Detection and Imaging of Intraventricular Hemorrhage in Neonatal Piglets Using Electrical Impedance Tomography
LI Yan-dong, SHI Xue-tao, DAI Meng, YOU Fu-sheng, XU Can-hua, FU Feng, LIU Rui-gang, WANG Liang, GAO Guo-dong, DONG Xiu-zhen
Intraventricular hemorrhage (IVH) is one of the most severe medical emergencies in neurosurgery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients. Although present medical imaging techniques have high sensitivity to identify bleeding, the use of an additional, non-invasive imaging technique capable of continuously monitoring IVH is required to prevent contingent bleeding or re-bleeding. In this study, electrical impedance tomography (EIT) was applied to detect the onset of IVH modeled on 6 piglets in real time, with the subsequent process being monitored continuously. The experimental IVH model was introduced by one-time injection of 2 ml fresh autologous arterial blood into the ventricles of piglets. Results showed that resistivity variations within the brain caused by the added blood could be detected and imaged
in vivo
using the EIT method, and the magnitude and the size of region of interest on EIT images may be linearly associated with the volume of the blood. In conclusion, EIT has unique potential for use in clinical practice to provide invaluable real-time neuroimaging data for IVH after the improvement of electrode design, anisotropic realistic modeling, and instrumentation.
2018 Vol. 27 (2): 57-67 [
Abstract
] (
70
)
HTML
(1 KB)
PDF
(7502 KB) (
13
)
68
Muscle Strength Measurement and Analysis of Chinese Young Males
ZHOU Qian-xiang, LIU Zhong-qi
To establish a database of muscle strength of the Chinese people. The study sampled data of 843 Chinese young males all over the country. Back force, hand twisting force and arm force of four different exerting directions (pull, push, adduction and abduction) were measured. Comparisons were made between the results of this study and those from other documents. Different types of the strength were also compared. The factors of stature and weight influenced on muscle force were analyzed. There are obvious difference of arm strength in four directions, which can be ordered as push, pull, adduction and abduction, the push force is the largest and the abduction force is the least. The significant correlation exists between different types force. Weight has an obvious influence on one’s force among above three factors. Chinese young males database is established at the first time. Results of the study can provide help for the ergonomists, the workers of occupation health and the researchers of rehabilitation.
2018 Vol. 27 (2): 68-73 [
Abstract
] (
75
)
HTML
(1 KB)
PDF
(3657 KB) (
168
)
74
Adaptive Dose-Compensation Technique for Image-Guided Radiotherapy of Prostate Cancer
WU Qiu-wen
Background:
For image-guided radiotherapy (IGRT) of prostate cancer, the current standard is online image guidance which can effectively correct setup errors and inter-fraction rigid organ motion. However, planning margins are still necessary for deformation and intra-fraction motion.
Objective:
This paper aims to investigate an adaptive planning technique incorporating offline dose feedback to manage interfraction motion and residuals from online corrections.
Methods:
Repeated CT scans from 28 patients were studied. Online IG was simulated by matching center-of-mass of prostate. A seven-beam IMRT plan with zero margins was designed for each patient. Dose distribution at each fraction was evaluated based on actual target and OARs from that fraction. Cumulative dose was calculated using deformable registration and compared to initial plan. If deviation exceeded pre-defined 2% threshold in prostate D
99
an adaptive planning technique called dose compensation was invoked, in which cumulative dose was fed back to the planning system and dose deficit was made up through boost radiation in future fractions through IMRT.
Results:
If 2% under-dose was allowed at the end of course, then 11 patients failed. If the same criteria was assessed at the end of each week (every 5 fractions), then 14 patients failed. The average dose deficit for these 14 patients was 4.4%. They improved to 2% after weekly compensation. 10 (out of 14) patients passed criterion after weekly dose compensation; 3 failed marginally; 1 failed significantly (10% deficit). A more aggressive compensation frequency (every 3 fractions) could reduce the dose deficit to the acceptable level for this patient. The doses to OARs were not significantly different from online IG only without dose compensation.
Conclusion:
We demonstrated an offline dose compensation technique in prostate IGRT which can effectively account for residual uncertainties uncorrectable in online IG. Dose compensation allows further margin reduction and critical organs sparing.
2018 Vol. 27 (2): 74-80 [
Abstract
] (
23
)
HTML
(1 KB)
PDF
(4874 KB) (
87
)
81
Neurofeedback Treatment Study for ADHD by Using the Brain-Computer Interface Neurofeedback System
LIU Tian, WANG Jue, CHEN Yan-ni, WANG Rong, SONG Meng
Neurofeedback or electroencephalogram (EEG) biofeedback technology is widely used in clinical rehabilitation field. In this paper, we used a brain-computer interface (BCI) neurofeedback system for attention deficit hyperactivity disorder (ADHD) children treatment.After 20 training sessions, integrated visual and auditory-conhnuous performance test (IVA-CPT), DSM-IV and conner scale results suggested that the attention of subjects had been strengthened, which showed that the BCI neurofeedback system could provide an effective therapy for treating ADHD children.
2018 Vol. 27 (2): 81-86 [
Abstract
] (
19
)
HTML
(1 KB)
PDF
(3738 KB) (
97
)
87
Medical Devices Standardization System in China
YANG Xiao-fang, WANG Chun-ren, LI De-yu
The standardization system is imperfect since the complexity of the medical devices and the specialty of the medical device industry in China. This paper describes the present situation of medical devices standardization system in China, reviews and discusses the advantages and problems of the medical devices standardizatiom. It also presents some comments and suggestions to perfect the medical devices standardization system for enhancing the quality control of medical devices and for promoting the development of medical devices industry.
2018 Vol. 27 (2): 87-91 [
Abstract
] (
20
)
HTML
(1 KB)
PDF
(4054 KB) (
132
)
Copyright © Editorial Board of Chinese Journal of Biomedical Engineering
Supported by:
Beijing Magtech
