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	中国生物医学工程学会

	北京玛格泰克科技发展有限公司

2019 Vol. 28, No. 1 Published: 2019-03-01

Research papers

Research papers

	1	The Value of Blood Tumor Markers in the Prognosis of Patients with Unresectable Locally Advanced or Metastatic Gastric Cancer before First-line Chemotherapy
		SUN Zhi-wei, JIA Jun, DU Feng, LIU Chuan-ling, YU Jing, YANG Ying, XIAO Yan-jie, ZHANG Xiao-dong
		Objective: To study the significance of CEA, CA199, CA72.4 and CA125 in the peripheral blood of patients with advanced or metastatic gastric cancer. Methods: The clinical data of 109 patients with non-operative local advanced or metastatic gastric cancer who received first-line chemotherapy in our center from July 2013 to May 2015, and the detection results of CEA, CA199, CA72.4 and CA125 tumor markers before chemotherapy were retrospectively collected, and their correlation with the clinicopathological characteristics and prognosis of the patients were analyzed.Results: The positive rates of CEA, CA199, CA72.4 and CA125 were 46.8%, 40.2%, 53.5% and 35.0% respectively in 109 cases of gastric cancer, and the positive rates of combined detection of four markers were 87.2%. CEA positive was significantly correlated with liver metastasis (P=0.014), CA125 positive with peritoneal metastasis (P=0.005). In univariate analysis, median PFS (6.3 months vs 11.1 months, P=0.020) and median OS (9.9 months vs 16.9 months, P=0.007) of CA72.4 positive subjects were significantly shorter than those of negative subjects, and median PFS (6.2 months vs 7.8 months, P=0.002) and median OS (9.8 months vs 15.6 months, P=0.009) of CA125 positive subjects were significantly shorter than those of negative subjects. 95% CI 1.016-29.601). Of 109 patients, 49 (45.0%) were low-risk group (0 or 1 risk factor), 60 (55.0%) were high-risk group (2 to 4 risk factors). The median survival time of low-risk and high-risk groups was 18.5 months and 9.9 months, respectively (P=0.001). Conclusion: CA72.4 and CA125 are related to the prognosis of patients with local advanced or metastatic gastric cancer, and the prognosis model is helpful to stratify the risk of patients and provide the best treatment plan for each patient.
		2019 Vol. 28 (1): 1-12 [Abstract] ( 25 ) HTML (1 KB) PDF (6183 KB) ( 101 )

	13	Comparison of the Safety and Effectiveness of Lower Extremity Artery Bypass Grafting and Endovascular Angioplasty in the Treatment of Lower Extremity Arteriosclerosis Obliterans in the Elderly
		LI Gang-zhi, ZHAO Jin-jie, MA Ronga, LI Lan-lan, ZHAO Jing-hao
		Objective: To compare the safety and effectiveness of lower extremity artery bypass grafting and endovascular angioplasty in the treatment of lower extremity arteriosclerosis obliterans in the elderly. Methods: The data of 87 elderly patients with lower extremity arteriosclerosis obliterans treated in our hospital from August 2015 to August 2017 were analyzed retrospectively. According to the different treatment methods, they were divided into angioplasty group (n=45, intravascular angioplasty) and bypass grafting group (n=42, lower extremity artery bypass grafting). The success rate, hemodynamics of dorsalis pedis artery and nerve conduction of lower extremity were compared between the two groups Velocity, VAS score, late target vessel lumen loss (LLL), patency rate, restenosis rate, ankle brachial index (ABI) and clinical adverse events. Results: There was no significant difference between angioplasty group and bypass group (P>0.05). One month after operation, the hemodynamics of dorsalis pedis artery and nerve conduction velocity of lower limbs in the two groups were better than those before operation, the difference was statistically significant (P<0.05), but there was no significant difference between the two groups (P>0.05). The VAS score of the two groups was significantly lower than that of the preoperative group (P<0.05), but there was no significant difference between the two groups (P>0.05). The ABI of the two groups was significantly improved after operation, the difference was statistically significant (P<0.05), but there was no significant difference between the groups at each time point (P>0.05). There was no significant difference in LLL, patency rate and restenosis rate between the two groups (P>0.05). There was statistical difference in the incidence of complications between the two groups (P<0.05). During the follow-up period, no serious adverse events such as death or amputation occurred in both groups. Conclusion: Endovascular angioplasty and lower extremity artery bypass grafting have the same clinical effect in the treatment of elderly patients with lower extremity arteriosclerosis obliterans, which are safe and feasible.
		2019 Vol. 28 (1): 13-21 [Abstract] ( 19 ) HTML (1 KB) PDF (5847 KB) ( 122 )

	22	Study on the Influencing Factors of Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma
		JI Tian-long
		Objective: To investigate the influencing factors of the cervical lymph node metastasis in papillary thyroid microcarcinoma (PTMC) and to provide a theoretical basis for cervical lymph node dissection. Methods: A total of 80 PTMC patients treated in the Department of Breast and Thyroid Surgery of our Hospital from January 2017 to January 2018 were selected in the study. All the patients accepted the first surgical treatment and were confirmed by pathology. The clinical data of all PTMC patients were retrospectively analyzed, and the related factors such as gender, age, number of primary lesions, tumor diameter and extrathyroidal invasions were analyzed. The factors that actually affected the lymph node metastasis of PTMC patients were explored. Results: All patients underwent prophylactic central lymph node dissection. Lymph node metastasis occurred in 26 patients in the central region and in 13 patients in the lateral neck region. The rate of lymph node metastasis in the central region of men was 41.18%, and the rate of lymph node metastasis in the lateral neck region was 23.53%, which were significantly higher than that of women's 30.16% and 14.29%. The differences were statistically significant (P<0.05). The regional metastasis rate of the patients of ≤45 years was 45.83%, and the lateral neck region metastasis rate was 20.83%, which were significantly higher than those of patients >45 years old (12.50%, 9.38%) and the differences were statistically significant (P<0.05). The lymph node metastasis rate in the central region and in the lateral neck region of tumor diameter <0.5 cm were 27.27% and 9.09% respectively, which were significantly lower than those of the tumor diameter 0.5-1.0 cm (38.89%, 25.00%) (P<0.05). The rate of lymph node metastasis in the central region of single focus was 20.37%, which was significantly lower than that of 57.69% in the multifocal lesions; the rate of lymph node metastasis in the cervical region of the single lesion was 11.11%, which was significantly lower than 26.92% in the multifocal area; the differences were statistically significant (P<0.05). The metastasis rate of the patients with extrathyroidal invasions in the central area was 60.00%, which is significantly higher than that without extrathyroidal invasions (30.67%). About the tumor neck invasion of the lateral neck region, the lymph node metastasis rate of the patients with extrathyroidal invasions was 40.00%, which was significantly higher than that without extrathyroidal invasions(14.67%). The differences were statistically significant (P<0.05). Logistic regression analysis showed that gender and tumor size were independent influencing factors of lymph node metastasis in the central and lateral neck regions (P<0.05). Conclusion: Young, male, multifocal, tumor diameter 0.5-1.0 cm and extrathyroidal invasions are risk factors for cervical lymph node metastasis in patients with PTMC. Gender and tumor size are independent factors affecting central/lateral cervical lymph node metastasis in PTMC patients.
		2019 Vol. 28 (1): 22-29 [Abstract] ( 20 ) HTML (1 KB) PDF (5175 KB) ( 94 )

	30	A Rapid Processing Technology of Water Quality Microfluidic Chip
		MA Xin-hua, OU Guo-rong, LIU Nan
		In this study, a unique rapid processing technology for microfluidic chips made of polymethylmethacrylate (PMMA) was realized. The common laser engraving machine is used to etch the chip reaction unit and microchannel, and the printing chip is what you see is what you get; the pressurized heat sealing technology is used to quickly complete the chip sealing and packaging; the metal electrodes and lines that need to be laid are embedded into the chip by hot melting; the contact points on the fixed base of the contact chip card are used to connect with the external equipment, so as to make the bearing sample react, detect and complex lines and chips. It is self-contained and isolated from the external equipment circuit. The chip becomes disposable and can be replaced quickly and conveniently. The chip processed by this technology has rapid, cheap and convenient improvement and innovation, which makes the production of microfluidic chip easier and more practical, and even makes the chip a disposable consumable with general interface, which will greatly promote the industrialization of microfluidic chip, and has market-oriented promotion value in the field of water quality and food detection.
		2019 Vol. 28 (1): 30-35 [Abstract] ( 19 ) HTML (1 KB) PDF (3000 KB) ( 111 )

	36	Comparison of Three External Wet Compress Methods in The Treatment of Facial Hormone Dependent Dermatitis
		KANG Xiao-fang, XU Hua-qiang
		Objective: To compare the therapeutic effects of three different external wet compress methods on facial hormone dependent dermatitis (FCAD), and to provide reference for clinical treatment of FCAD. Methods: From June 2016 to June 2019, 160 FCAD patients in our dermatology clinic were selected and divided into three groups according to random number table: the first group was treated with Compound Cortex Phellodendri liquid coating, the second group was treated with collagen paste dressing, and the third group was treated with 0.9% sodium chloride injection solution. Apply 8 layers of gauze or cold compress directly to the skin lesions for 4 weeks in each group. Results: After 4 weeks of treatment, no adverse reactions were found. The effective rates of the first group, the second group, and the third group were 72.22%, 62.26% and 41.51%, respectively. Compared with the third group, the effective rate of the first group and the second group was significantly higher, and there was statistical significance between the groups ( χ²=10.294, χ²=4.573, P<0.05); but there was no significant statistical difference between the first group and the second group ( χ²=1.205, P>0.05).Conclusion: Compound Cortex Phellodendri coating is suitable for FCAD patients with severe inflammation, collagen paste dressing is suitable for FCAD patients with mild to moderate inflammatory reaction and pigmentation, and 0.9% sodium chloride injection is suitable for patients with mild facial flushing and swelling. Clinical treatment should be selected according to the patient's condition and rash characteristics.
		2019 Vol. 28 (1): 36-40 [Abstract] ( 44 ) HTML (1 KB) PDF (3138 KB) ( 196 )

	41	Finite Element Analysis of the Frequency Response of a Microbubble Under Ultrasonic Field
		QIU Xiao-hui, ZHOU Yan-hong, PENG You-lin, ZHOU Li-li, WANG Xiao-jian
		The finite element numerical models of the microbubble with and without shell are built in our study. The calculation results indicate that the frequency response of the shell-microbubble is different from that of microbubble without shell. Furthermore, the frequency response of microbubble is closely related to the relevant parameters of the shell. The thickness and the Young's modulus willinfluence the frequency response. The increase of the thickness or the Young's modulus of the shell leads to the increase of the resonance frequency and the decrease of the oscillation amplitude of the microbubble.
		2019 Vol. 28 (1): 41-46 [Abstract] ( 19 ) HTML (1 KB) PDF (2432 KB) ( 89 )

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