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| SIRT1 Protects Cortical Neurons from Shear Stress Induced Mechanical Injury |
| WEI Song, LIU Mei-li, LI Ping, ZHOU Gang, FAN Yu-bo |
| Key Lab for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China |
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Abstract Emerging evidence implicates that SIRT1, one of NAD-dependent protein deacetylase, is involved in the regulation of neuronal survival. However, the role of SIRT1 in mechanical injury is still unclear. Here, we first established a mechanical injury model of rat cortical neurons through exposing to 10 dyn/cm2 laminar shear stress for 4 h. At the same time, we found that SIRT1 expression increased during the process of shear stress induced neuronal injury. SIRT1 overexpression in cortical neurons significantly decreased the percentage of died cells induced by shear stress. Our results demonstrate that SIRTl may play potential neuroprotective effects in shear stress induced mechanical injury.
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Received: 05 September 2019
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| Fund:National Science Foundation of China; grant number: 10925208, 1120101001, 10802006 and 31100666; grant sponsor: the Fundamental Research Funds for the Central Universities; grant number: YWF-10-02-065 |
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Corresponding Authors:
FAN Yu-bo. E-mail: yubofan@buaa.edu.cn
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