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| Electrical Impedance Tomography after Cerebral Ischemic |
| CHEN Chao-shuang1, FU Feng1, LI Bing2, LIU Wen-bo2, XU Shi-wei1, TAO Feng1, SHI Xue-tao1, YANG Lin1, FEI Zhou2, DONG Xiu-zhen1 |
l.Department of Biomedical Engineering, Fourth Military Medical University, Shanxi Province Xi'an 710032, China;
2.Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Shanxi Province Xi'an 710032, China |
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Abstract Intracerebral haemorrhage (ICH), which has rapid attack and high death rate, usually leads to bad outcomes. Poor prognosis of this disease is primarily due to the difficulty of early discovery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients. The purpose of this paper is to testify electrical impedance change and detection of brain tissue after cerebral ischemic with electrical impedance tomography. In this study, electrical impedance tomography (EIT) was applied to detect the onset of modeled on rabbits in real time, ICH model group were injected collagenase in the Corpus Striatum while rabbits in control group were injected the same volume of saline with collagenase. The subsequent process was monitored continuously by system of electrical impedance tomography;the rabbits were sacrificed by intravenous injection of over dose of hydration chlorine aldehyde, and then taken into being scanned by computed tomography (CT) with a resolution of l mm within 10 min after death. After that, the brains of the rabbits were taken out, fixed and cut into slices to detect the changes of brain tissue. We found that one- dimensional impedance and two-dimensional(2D) images of electric resistance of brain of the rabbits pretreated with collagenase obviously changed after injection and the hemorrhage could be found in the slices of brain and there were changes in the model rabbits group not only the electric resistance but also the brain tissues. Although quantitative index can't be provided by detection of intracerebral hemorrhage in rabbits with electrical impedance tomography's at this stage, cerebral hemorrhage can cause brain electrical impedance characters of the change, the completed experiments suggest that electrical impedance tomography (EIT) may become an effective technique to detect ICH.
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Received: 20 April 2017
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| Fund:National Natural Science Foundation of China; grant number:30870653; the National Science and Technology Support Program; 2009BAI79B03 |
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Corresponding Authors:
CHEN Chao-shuang, DONG Xiu-zhen. E-mail: cslovehy@yahoo.com.cn
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