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| Enhanced External Counterpulsation Treatment Inhibitting Advanced Atherosclerotic Plaque Progression by Augmenting the Plaque Wall Stress: An in vivo FSI Study Based on Animal Experiment |
| DU Jian-hang1,2, HUANG Liang2, WU Gui-fu3,4, ZHENG Zhen-sheng4,
FENG Ming-zhe4, DAI Gang4,WU Fu-jun4 |
1. School of Engineering, Guangdong Ocean University, Guangdong Province Zhanjiang 524088, China；
2. Mathematical Sciences Department, Worcester Polytechnics Institute, MA 01609, USA；
3. The Affiliated Futian Hospital of Guangdong Medical College, Guangdong Province Shenzhen 518000, China；
4. Key Laboratory on Assisted Circulation, Ministry of Health, Guangdong Province Guangzhou 510089, China |
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Abstract Enhance external counterpulsation (EECP) procedure has exhibited itself to be an effective therapy for the management of ischemic cardiovascular diseases. However, considering that EECP significantly increases the acute diastolic pressure, whether it will intervene in the chronic progression of advanced plaque causing great concern in clinical application, but yet remains elusive presently. In the current paper, a fluid-structure interface (FSI) numerical model of artery with plaque component was developed based on in vivo hemodynamic measurement performed in a porcine model, to calculate the mechanical stresses of the plaque before and during EECP, and in turn to assess the potential effects of long-term EECP treatment on plaque progression. The results show that EECP augmented the wall shear stress (WSS) and plaque wall stress (PWS) over the cardiac cycles, as well as the spacial oscillatory of WSS (WSSG). During EECP treatment, the PWS level respectively raised 6.82% and 6.07% in two simulation cases. The current pilot study suggests that EECP treatment may play a positive effect on inhibiting the continued plaque progression by increasing the PWS level over the cardiac cycles. Meanwhile, the plaque morphology should be taken into consideration while making patient-specific plan for long-term EECP treatment in clinic.
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Received: 12 December 2015
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Corresponding Authors:
DU Jian-hang. E-mail: Jianhang.Du@yahoo.com
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