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| The Influence of RNA Secondary Structure on the Efficiency of siRNA Silencing |
| SUN Ying, GUI Jian-bin, CHEN Zhao-xue |
| Medical Instrument and Food Engineering College, University of Shanghai for Science and Technology, Shanghai 200093, China |
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Abstract In the application of RNAi technology, it is an essential step to design siRNA applicable to target gene. At present, there are many researches and conclusions on siRNA design. This paper aims to the influences of mRNA secondary structure or siRNA antisense-strand secondary structure on siRNA silence efficiency. The paper also discusses the problems and sets out further insights in the research.
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Received: 24 September 2015
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Corresponding Authors:
SUN Ying. E-mail: yysyysun@163.com
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