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| The Function of Surfeit 4 Gene in vivo |
| ZHAO Yan1, YU Hong2 |
1. Department of Pathology and Pathophysiology, Nantong University School of Medicine, Nantong Jiangsu 226007, China;
2. Department of Pathology, the Fifth Affiliated Hospital of Nantong University/Taizhou People's Hospital, Taizhou Jiangsu 225300, China |
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Abstract Surfeit 4(Surf 4), one of the identified housekeeping genes, was previously thought to encode a transmembrane protein that acts as a cargo receptor to maintain basic cellular functions. In recent years, Surf 4 gene is overexpressed in some types of cancer, involved in the exosome signaling pathway in gastrointestinal stromal tumors, and played the role of an oncogene in ovarian cancer stem cells. In this paper, we review the characteristics and protein localization of Surf 4 gene, as well as its possible physiological functions and pathogenesis in various diseases and cancers, expecting to discuss its clinical application value.
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Received: 15 April 2022
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| Fund:The Scientific Research Fund of Jiangsu Provincial Department of Health; grant number: H2017075; Taizhou People's Hospital Innovation Team Fund; grant number: CXTDB201904. |
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Corresponding Authors:
YU Hong. E-mail: 15961057718@163.com
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