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Application Value of Macrogene II Sequencing in IPA Diagnosis and Treatment |
ZHOU Ting-ting, LI Yu-yan, SONG Li-ying, WANG Shuang-ge |
Jilin Kingmed for Clinical Laboratory Co., Ltd., Changchun Jilin 130000, China |
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Abstract Infectious diseases feature multiple pathogens, complicated and diverse clinical symptoms. Early and accurate detection of infectious pathogens sets the foundation for its targeted clinical treatment. With long detection cycles and low positive rates, traditional detection approaches such as Gram-stained smear microscopy and specific marker detection can barely meet the clinical needs for infectious disease detection. As a new gene detection technology, macrogene II sequencing can enable higher detection efficiency for infectious diseases caused by pathogens such as fungi and bacteria, demonstrating certain application value. This paper describes invasive pulmonary aspergillosis (IPA), concepts concerning macrogene II sequencing, as well as its application value for invasive pulmonary aspergillosis.
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Received: 19 December 2021
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Corresponding Authors:
WANG Shuang-ge. E-mail: 516273533@qq.com
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[1] Peng JM, Du B, Qin HY, et al.Metagenomic next-generation sequencing for the diagnosis of suspected pneumonia in immunocompromised patients[J].J Infect, 2021, 82(4):22-27. [2] Ledoux MP, Guffroy B, Nivoix Y, et al.Invasive pulmonary aspergillosis[J].Semin Respir Crit Care Med, 2020, 41(1):80-98. [3] Tudesq JJ, Peyrony O, Lemiale V, et al.Invasive pulmonary aspergillosis in nonimmunocompromised hosts[J].Semin Respir Crit Care Med, 2019, 40(4):540-547. [4] Lai CC, Yu WL.COVID-19 associated with pulmonary aspergillosis: A literature review[J].J Microbiol Immunol Infect, 2021, 54(1):46-53. [5] Wauters J, Lamoth F, Rijnders BJA, et al.Invasive pulmonary aspergillosis goes viral again[J].Am J Respir Crit Care Med, 2021, 203(3):275-277. [6] Alanio A, Dellière S, Fodil S, et al.Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19[J].Lancet Respir Med, 2020, 8(6):48-49. [7] Russo A, Tiseo G, Falcone M, et al.Pulmonary aspergillosis: An evolving challenge for diagnosis and treatment[J].Infect Dis Ther, 2020, 9(3):511-524. [8] Bulpa P, Duplaquet F, Dimopoulos G, et al.Invasive pulmonary aspergillosis in chronic obstructive pulmonary disease exacerbations[J].Semin Respir Crit Care Med, 2020, 41(6):851-861. [9] Torres A, Martin-Loeches I.Invasive pulmonary aspergillosis in ventilator-associated pneumonia: The hidden enemy[J]? Am J Respir Crit Care Med, 2020, 202(8):1071-1073. |
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