摘要Objective:To observe the effect of bilateral transcranial direct current stimulation(tDCS) on the brain functional network in patients with upper limb spasm after stroke. Methods: An electroencephalograph (EEG) was used to analyze the effect of the brain functional network before and after the intervention of bilateral tDCS in patients with secondary upper limb spasm after stroke. A total of 44 patients with upper limb spasm after stroke were randomly divided into a real stimulation group and a sham stimulation group. Bilateral tDCS interventions were carried out respectively. The parameters of the brain functional network measured by EEG and the cross-correlation coefficients between various leads before the experiment and at 5 days after the experiment were compared. Results: During the imagination of grasping a mineral water bottle, the degree of nodes in the real stimulation group after stimulation was higher than that before stimulation and that of the sham stimulation group at the same period(P=0.004); during the imagination of releasing the mineral water bottle, the clustering coefficient and global efficiency of nodes in the real stimulation group were both higher than those of the sham stimulation group at the same period (P=0.020, 0.032). Before stimulation, the importance scores of the degree of nodes among various leads ranged from 0.562 to 2.081. Among them, the importance scores of Pz, Oz, FP1, FP2, F3, F4, P4, O1, O2, F8, T5, C3, and Fz were all >1. After stimulation, the importance scores of all leads were >1, ranging from 1.911 to 5.580. The real stimulation group had a more obvious effect on P3, O1, O2, Cz, Oz, T4, T6, Fz, FP1, and T5. Conclusion: Bilateral tDCS intervention can enhance the degree of nodes during the imagination of grasping in patients with upper limb spasm after stroke, and enhance the clustering coefficient and global efficiency of nodes during the imagination of releasing. The brain functional network mainly has a more obvious impact on the brain functional areas of the leads in the parietal lobe, occipital lobe, central midline, occipital midline, middle temporal, posterior temporal, parietal midline, and frontal pole regions.
Abstract：Objective:To observe the effect of bilateral transcranial direct current stimulation(tDCS) on the brain functional network in patients with upper limb spasm after stroke. Methods: An electroencephalograph (EEG) was used to analyze the effect of the brain functional network before and after the intervention of bilateral tDCS in patients with secondary upper limb spasm after stroke. A total of 44 patients with upper limb spasm after stroke were randomly divided into a real stimulation group and a sham stimulation group. Bilateral tDCS interventions were carried out respectively. The parameters of the brain functional network measured by EEG and the cross-correlation coefficients between various leads before the experiment and at 5 days after the experiment were compared. Results: During the imagination of grasping a mineral water bottle, the degree of nodes in the real stimulation group after stimulation was higher than that before stimulation and that of the sham stimulation group at the same period(P=0.004); during the imagination of releasing the mineral water bottle, the clustering coefficient and global efficiency of nodes in the real stimulation group were both higher than those of the sham stimulation group at the same period (P=0.020, 0.032). Before stimulation, the importance scores of the degree of nodes among various leads ranged from 0.562 to 2.081. Among them, the importance scores of Pz, Oz, FP1, FP2, F3, F4, P4, O1, O2, F8, T5, C3, and Fz were all >1. After stimulation, the importance scores of all leads were >1, ranging from 1.911 to 5.580. The real stimulation group had a more obvious effect on P3, O1, O2, Cz, Oz, T4, T6, Fz, FP1, and T5. Conclusion: Bilateral tDCS intervention can enhance the degree of nodes during the imagination of grasping in patients with upper limb spasm after stroke, and enhance the clustering coefficient and global efficiency of nodes during the imagination of releasing. The brain functional network mainly has a more obvious impact on the brain functional areas of the leads in the parietal lobe, occipital lobe, central midline, occipital midline, middle temporal, posterior temporal, parietal midline, and frontal pole regions.
WANG Yuan. The Effect of Bilateral Transcranial Direct Current Stimulation (tDCS) on the Brain Functional Network in Patients with Upper Limb Spasm after Stroke[J]. 中国生物医学工程学报(英文版）, 2024, 33(4): 178-184.
WANG Yuan. The Effect of Bilateral Transcranial Direct Current Stimulation (tDCS) on the Brain Functional Network in Patients with Upper Limb Spasm after Stroke. Chinese Journal of Biomedical Engineering, 2024, 33(4): 178-184.
[1] Feske SK.Ischemic stroke[J]. Am J Med,2021,134(12): 1457-1464. [2] Friehs MA, Frings C, Hartwigsen G.Effects of single-session transcranial direct current stimulation on reactive response inhibition[J]. Neurosci Biobehav Rev,2021,128: 749-765. [3] Blaschke SJ, Vlachakis S, Pallast N, et al.Transcranial direct current stimulation reverses stroke-induced network alterations in mice[J]. Stroke,2023,54(8): 2145-2155. [4] Favaretto C, Allegra M, Deco G, et al.Subcortical-cortical dynamical states of the human brain and their breakdown in stroke[J]. Nat Commun,2022,13(1): 5069. [5] Gold J, Ciorciari J.Impacts of transcranial direct current stimulation on the action observation network and sports anticipation task[J]. J Sport Exerc Psychol,2021,43(4): 310-322. [6] Ma ZZ, Wu JJ, Cao Z, et al.Motor imagery-based brain-computer interface rehabilitation programs enhance upper extremity performance and cortical activation in stroke patients[J]. J Neuroeng Rehabil,2024,21(1): 91. [7] Soleimani G, Kupliki R, Paulus M, et al.Dose-response in modulating brain function with transcranial direct current stimulation: From local to network levels[J]. PLoS Comput Biol, 2023,19(10): e1011572. [8] Haikalis NK, Hooyman A, Wang P, et al.Placebo effects of transcranial direct current stimulation on motor skill acquisition[J]. Neurosci Lett,2023,814: 137442. [9] Müller D, Habel U, Brodkin ES, et al.High-definition transcranial direct current stimulation (HD-tDCS) for the enhancement of working memory-A systematic review and meta-analysis of healthy adults[J]. Brain Stimul,2022,15(6): 1475-1485. [10] Liu J, Wang C, Qin W, et al.Cortical structural changes after subcortical stroke: Patterns and correlates[J]. Hum Brain Mapp,2023,44(2): 727-743.
