摘要Objective To access the correlations between characteristics of carotid plaque in MRI and ischemic stroke in patients with ≤50% carotid artery stenosis. Methods A total of 43 patients with ≤50% carotid artery stenosis were selected for ultrasound from September 2014 to February 2016. A further test using magnetic resonance (MR) black blood imaging examination were carried out to distinguish the anatomy of the vessel as well the composition of the atherosclerotic plaque with remarkable details. The relationship between carotid plaque characteristics in MRI and other risk factors of patients with ischemic stroke was analyzed by univariate and multivariate analysis. Results The mean follow-up time was 11.8 months. During the follow-up period, 4 of the 43 individuals experienced an ipsilateral ischemic stroke. Kaplan-Meier survival analysis showed the mean ischemic stroke free survival of patients with coronary heart disease (CHD) was significantly shorter than that in patients without CHD, which were 12.1 months and 18.7 months respectively (P=0.029). The mean ischemic stroke free survival of patients with intra-plaque hemorrhage (IPH) was significantly shorter than that in patients without IPH, which were 14.3 months and 18.6 months respectively (P=0.001). COX regression analysis showed that coronary heart disease (HR=27.4; 95% CI, 1.6-464.3; P=0.022) and IPH (HR=18.2; 95% CI, 2.7-123.3; P=0.003) were independent risk factors for ischemic stroke. Conclusion For patients with carotid artery stenosis ≤50%, IPH of carotid plaques and CHD are independent risk factors for ischemic stroke.
Abstract：Objective To access the correlations between characteristics of carotid plaque in MRI and ischemic stroke in patients with ≤50% carotid artery stenosis. Methods A total of 43 patients with ≤50% carotid artery stenosis were selected for ultrasound from September 2014 to February 2016. A further test using magnetic resonance (MR) black blood imaging examination were carried out to distinguish the anatomy of the vessel as well the composition of the atherosclerotic plaque with remarkable details. The relationship between carotid plaque characteristics in MRI and other risk factors of patients with ischemic stroke was analyzed by univariate and multivariate analysis. Results The mean follow-up time was 11.8 months. During the follow-up period, 4 of the 43 individuals experienced an ipsilateral ischemic stroke. Kaplan-Meier survival analysis showed the mean ischemic stroke free survival of patients with coronary heart disease (CHD) was significantly shorter than that in patients without CHD, which were 12.1 months and 18.7 months respectively (P=0.029). The mean ischemic stroke free survival of patients with intra-plaque hemorrhage (IPH) was significantly shorter than that in patients without IPH, which were 14.3 months and 18.6 months respectively (P=0.001). COX regression analysis showed that coronary heart disease (HR=27.4; 95% CI, 1.6-464.3; P=0.022) and IPH (HR=18.2; 95% CI, 2.7-123.3; P=0.003) were independent risk factors for ischemic stroke. Conclusion For patients with carotid artery stenosis ≤50%, IPH of carotid plaques and CHD are independent risk factors for ischemic stroke.
通讯作者:
Qian Wang, Department of Vascular Surgery, the First Affiliated Hospital of Tsinghua University, Beijing 100016, China. E-mail address: wangqianeu@126.com
引用本文:
Qian Wang, Sibo Liu, Anni Long, Jingzhe Liu, Xiaowei Zhang, Lei Li. Correlation between Carotid Plaque Characteristics without Operative Indication and Ischemic Stroke[J]. 中国生物医学工程学报(英文版）, 2020, 29(2): 17-24.
Qian Wang, Sibo Liu, Anni Long, Jingzhe Liu, Xiaowei Zhang, Lei Li. Correlation between Carotid Plaque Characteristics without Operative Indication and Ischemic Stroke. Chinese Journal of Biomedical Engineering, 2020, 29(2): 17-24.
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