摘要Objective: To investigate the expression of basic fibroblast growth factor (bFGF) and transforming growth factor β(TGF-β) in the transversalis fascia of female dogs with inguinal hernia. Methods: A total of 20 female dogs with inguinal hernia were selected as the research subjects, which were divided into two groups: the observation group (direct inguinal hernia female dogs, n=10) and the control group (indirect inguinal hernia female dogs, n=10). Immunohistochemistry was used to detect the expression of bFGF and TGF-β in the fascia transversalis. Results: The results showed that(1) The expression of bFGF and TGF-β was found to be positively linked with the speed of adhesion. The expression of bFGF and TGF-β significantly increased with the increase in adhesion speed; DAB staining revealed the presence of bFGF and TGF-β, with TGF-β showing diffuse or localized staining in the observation group. In contrast, the control group exhibited diffuse staining. In both the control group and the observation group, the bFGF exhibited either diffuse light staining or localized staining. (2)There was no statistically significant difference in bFGF levels between the observation group and the control group(P>0.05). The difference in TGF-β levels between the observation group and the control group was statistically significant (P<0.05). Conclusion: bFGF can be used to regulate the metabolism and synthesis of collagen in the body, thereby gradually changing the tensile strength of the transversalis fascia, which can have a significant impact on the occurrence and progression of inguinal hernia.
Abstract：Objective: To investigate the expression of basic fibroblast growth factor (bFGF) and transforming growth factor β(TGF-β) in the transversalis fascia of female dogs with inguinal hernia. Methods: A total of 20 female dogs with inguinal hernia were selected as the research subjects, which were divided into two groups: the observation group (direct inguinal hernia female dogs, n=10) and the control group (indirect inguinal hernia female dogs, n=10). Immunohistochemistry was used to detect the expression of bFGF and TGF-β in the fascia transversalis. Results: The results showed that(1) The expression of bFGF and TGF-β was found to be positively linked with the speed of adhesion. The expression of bFGF and TGF-β significantly increased with the increase in adhesion speed; DAB staining revealed the presence of bFGF and TGF-β, with TGF-β showing diffuse or localized staining in the observation group. In contrast, the control group exhibited diffuse staining. In both the control group and the observation group, the bFGF exhibited either diffuse light staining or localized staining. (2)There was no statistically significant difference in bFGF levels between the observation group and the control group(P>0.05). The difference in TGF-β levels between the observation group and the control group was statistically significant (P<0.05). Conclusion: bFGF can be used to regulate the metabolism and synthesis of collagen in the body, thereby gradually changing the tensile strength of the transversalis fascia, which can have a significant impact on the occurrence and progression of inguinal hernia.
YIN Yu-hu. Expression of bFGF and TGF-β in the Transversalis Fascia of Female Dogs with Inguinal Hernia[J]. 中国生物医学工程学报(英文版）, 2023, 32(2): 79-85.
YIN Yu-hu. Expression of bFGF and TGF-β in the Transversalis Fascia of Female Dogs with Inguinal Hernia. Chinese Journal of Biomedical Engineering, 2023, 32(2): 79-85.
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