Distribution of ApoE Gene Polymorphism and Significance of Auxiliary Diagnosis and Treatment of Cerebrovascular Diseases (Intracerebral Hemorrhage and Cerebral Thrombosis) in the Longyan Area
ZHANG Hong-bin, HE Xiang-sheng, YOU Yu-dong, FAN Zhi-quan, ZHANG Man'e, LU Zhi-hua
The Second Hospital of Longyan, Longyan Fujian Province 364000, China
Distribution of ApoE Gene Polymorphism and Significance of Auxiliary Diagnosis and Treatment of Cerebrovascular Diseases (Intracerebral Hemorrhage and Cerebral Thrombosis) in the Longyan Area
ZHANG Hong-bin, HE Xiang-sheng, YOU Yu-dong, FAN Zhi-quan, ZHANG Man'e, LU Zhi-hua
The Second Hospital of Longyan, Longyan Fujian Province 364000, China
摘要Objective: To make statistics on the distribution of ApoE gene polymorphism in the Longyan area, provide data for the statistics of regional cerebrovascular diseases, explore the significance of ApoE gene polymorphism distribution for clinical guidance, diagnosis and treatment, and provide more suggestions. for clinical diagnosis and treatment of cerebrovascular diseases. Methods: 800 patients with cerebrovascular disease in the Longyan area from July 2018 to April 2021 were selected as the research object, and 800 normal healthy patients were selected as the control group. The data were further analyzed according to the collected patient information, and the patients were distinguished according to age and other basic information, the type of cerebrovascular disease, ApoE gene polymorphism and blood lipid test results. The distribution of ApoE gene polymorphism in the cerebrovascular disease population in the Longyan area was given to determine the correlation between the incidence of cerebrovascular disease and the distribution of ApoE gene polymorphism. Results: In the study group, E2/E3 genotyping was the most common 400 (50.00%), and E4/E4 genotyping 6 (0.75%) was the least common; In the control group, E2/E4 genotyping was the most common 480(60.00%), and E2/E3 genotyping accounted for the second 290 (36.25%). In the study group, E3 allele was the most common 383 (47.88%), E4 allele 121 (15. 12%); in the control group, E2 allele was the most common 391 (48.88%), and E3 allele 142 (17.75%). Conclusion: According to the statistics of ApoE gene polymorphism distribution in the Longyan area and the analysis of the correlation of other cerebrovascular diseases, it is found that E2/E3 genotype may be related to cerebrovascular diseases, and E3 allele may be a susceptibility factor. Through the above analysis, the occurrence of diseases can be predicted and prerevented.
Abstract：Objective: To make statistics on the distribution of ApoE gene polymorphism in the Longyan area, provide data for the statistics of regional cerebrovascular diseases, explore the significance of ApoE gene polymorphism distribution for clinical guidance, diagnosis and treatment, and provide more suggestions. for clinical diagnosis and treatment of cerebrovascular diseases. Methods: 800 patients with cerebrovascular disease in the Longyan area from July 2018 to April 2021 were selected as the research object, and 800 normal healthy patients were selected as the control group. The data were further analyzed according to the collected patient information, and the patients were distinguished according to age and other basic information, the type of cerebrovascular disease, ApoE gene polymorphism and blood lipid test results. The distribution of ApoE gene polymorphism in the cerebrovascular disease population in the Longyan area was given to determine the correlation between the incidence of cerebrovascular disease and the distribution of ApoE gene polymorphism. Results: In the study group, E2/E3 genotyping was the most common 400 (50.00%), and E4/E4 genotyping 6 (0.75%) was the least common; In the control group, E2/E4 genotyping was the most common 480(60.00%), and E2/E3 genotyping accounted for the second 290 (36.25%). In the study group, E3 allele was the most common 383 (47.88%), E4 allele 121 (15. 12%); in the control group, E2 allele was the most common 391 (48.88%), and E3 allele 142 (17.75%). Conclusion: According to the statistics of ApoE gene polymorphism distribution in the Longyan area and the analysis of the correlation of other cerebrovascular diseases, it is found that E2/E3 genotype may be related to cerebrovascular diseases, and E3 allele may be a susceptibility factor. Through the above analysis, the occurrence of diseases can be predicted and prerevented.
ZHANG Hong-bin, HE Xiang-sheng, YOU Yu-dong, FAN Zhi-quan, ZHANG Man'e, LU Zhi-hua. Distribution of ApoE Gene Polymorphism and Significance of Auxiliary Diagnosis and Treatment of Cerebrovascular Diseases (Intracerebral Hemorrhage and Cerebral Thrombosis) in the Longyan Area[J]. 中国生物医学工程学报(英文版）, 2021, 30(4): 172-177.
ZHANG Hong-bin, HE Xiang-sheng, YOU Yu-dong, FAN Zhi-quan, ZHANG Man'e, LU Zhi-hua. Distribution of ApoE Gene Polymorphism and Significance of Auxiliary Diagnosis and Treatment of Cerebrovascular Diseases (Intracerebral Hemorrhage and Cerebral Thrombosis) in the Longyan Area. Chinese Journal of Biomedical Engineering, 2021, 30(4): 172-177.
[1] Zeng Chun, Sun Xiaochuan.Role of apolipoprotein E and its gene polymorphism in cerebral vasospasm after subarachnoid hemorrhage[J]. Chongqing Medicine, 2019, 41(36):3892. [2] Han Ruiling, Wan Zicheng, Sun Si, et al. Analysis of apolipoprotein E gene polymorphism in patients with large atherosclerotic ischemic stroke in Wuhan[J]. Neural Injury and Functional Reconstruction, 2018, 013(010): 492-494, 533. [3] Yu Xueying, Wang Na, Li Jiang, et al. Association between apolipoprotein E gene polymorphism and cerebral infarc-tion in patients with type 2 diabetes mellitus[J]. Chinese Jourmnal of Laboratory Medicine, 2020, 43(2):160-164. [4] Liu Yanxia, Zhang Cong, Han Xia, et al. Effect of ApoE gene polymorphism on the efficacy of rosuvastatin in elderly patients with coronary heart disease[J]. Chinese Journal of Clinical Healthcare, 2020, 023(002):188-191. [5] Zhang Xuxiang, Li Wen, Wang Fang, et al. Association between APOE gene polymorphism and type 2 diabetes mellitus in Yunnan Dai[J]. Journal of Kunming Medical University, 2020(5):18-22. [6] GuiYuqi, Guo Yijing, Liu Yuyu, et al. Effects of ApoE gene polymorphism and its interaction with environmental factors on carotid atherosclerosis[J]. Journal of Southeast University(Medical Science Edition), 2020, 39(02):61-66. [7] Gao Yinting, Kong Lulu, Li Wei.Relationship between apolipoprotein E gene polymorphism and cerebrovascular complications in patients with type 2 diabetes mellitus[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascu-lar Disease, 2020, 28(12):51-56. [8] Wang Gaoju, Jiao Hongjun, Zhou Jianhua.Effect of ApoE gene polymorphism on the efficacy of rosuvastatin in the treatment of hyperlipidemia and its mechanism[J]. Chinese Journal of Hospital Pharmacy, 2020, 40(19):23-28, 35. [9] Klop B, Verseyden C, Ribalta J, et al. MTP gene polymorphisms and postprandial lipemia in familial combined hyperlipidemia: Effects of treatment with atorvastatin [J]. Clinica E Investigacion En Arteriosclerosis Publicacion Off-cial De La Sociedad Espanola De Arteriosclerosis, 2014, 26(2):49-57. [10] Ji Weizhong, Wu Shizheng, Hou Qian, et al. Relationship between apolipoprotein E gene polymorphism and cere-brovascular disease in Qinghai Tibetan[J].Chinese Jourmal of Nervous and Mental Diseases, 2019, 45(4):19-23. [11] Liu Tingting, Shi Haifeng, Liu Jing.Clinical distribution characteristics of ApoE gene polymorphism and its correla-tion with blood lipid level in patients with acute cerebrovascular disease[J]. Journal of Modern Laboratory Medicine, 2019, 034(003):25-29. [12] Song Yu, Tian Shufen.Correlation between ApoE gene polymorphism and cerebral microbleeds in patients with is-chemic cerebrovascular disease[J]. Jourmal of Shandong University(Health Sciences), 2019, 57(4):47-51, 58. [13] Li Shuzhi, Zhou Jun, Zhao Yueming, et al. Clinical correlation between apolipoprotein E gene polymorphism and cerebral amyloid angiopathy related intracerebral hemorrhage[J]. Chinese Journal of Neurotraumatic Surgery (Electronic Edition), 2019, 5(04):36-39. [14] Xie Li, Hong Mao, Liu Tao, et al. Analysis of SLCO1B1 and apoE gene polymorphisms in patients with hyperlipidemia and their correlation with blood lipid levels[J]. Labeled Immunoassays and Clinical Medicine, 2019, 026(010): 1723-1728. [15] Bai Jianfeng, Yu Liang, Sui Qiangbo.Apolipoprotein E gene polymorphism and its relationship with blood lipid level in patients with intracerebral hemorrhage at different ages[J]. Chinese Journal of Primary Medicine and Pharmacy, 2020, 027(009):1085-1089. [16] Jia Zhiqiang, Wu Xiuguo, Hu Shite, et al. Relationship between ApoE gene polymorphism and postoperative cognitive impairment in elderly patients[J]. Chinese Journal of Anesthesiology, 2019, 39(12):1421-1424. [17] Yan Hengyu, Xie Ping, Li Yanling, et al. Relationship between ApoE and SLCO1 B1 gene polymorphism and genotype and blood lipid level in Gansu Province[[J].Chinese Heart Journal, 2019, 31(01):46-49. [18] Zhao Ling, Ke Tingyu, Guo Jia, et al. Correlation between SLCO1B1 gene polymorphism and type 2 diabetic nephropathy%SLCO1B1[J]. Journal of Medical Research, 2019, 048(006):46-50. [19] Ruan H, Zhan L, Wang Z, et al. SLCO1B1& ApoE gene polymorphism analysis of the Li people in hainan island and its clinical significance[J]. Journal of Biomedical Science and Engineering, 2021, 14(3):130-141. [20] Chiasson JL, Aris-Jilwan N, Belanger R, et al. Diagnosis and treatment of diabetic ketoacidosis and the hyper-glycemic hyperosmolar state[J]. Canadian Medical Association Journal, 2003, 168(7):859.
