摘要The novel coronavirus (2019 novel coronavirus, 2019-nCoV) is a newly emerged virus. Therefore, the nucleic acid detection technology and serum immunological detection technology established urgently in emergencies have certain defects inevitably. The efficiency of nucleic acid and antibody detection varies at different stages of disease progression of the novel coronavirus disease (COVID-19). If the two can be used in combination and the results of the analysis can be comprehensively judged, they can be combined to monitor the viral load and disease progress better and improve the diagnostic efficiency. Based on the author's application experience, this article analyzes and interprets eight common modes of combined detection of nucleic acids and specific antibodies in order to provide a reference for the clinical diagnosis and treatment of COVID-19.
Abstract：The novel coronavirus (2019 novel coronavirus, 2019-nCoV) is a newly emerged virus. Therefore, the nucleic acid detection technology and serum immunological detection technology established urgently in emergencies have certain defects inevitably. The efficiency of nucleic acid and antibody detection varies at different stages of disease progression of the novel coronavirus disease (COVID-19). If the two can be used in combination and the results of the analysis can be comprehensively judged, they can be combined to monitor the viral load and disease progress better and improve the diagnostic efficiency. Based on the author's application experience, this article analyzes and interprets eight common modes of combined detection of nucleic acids and specific antibodies in order to provide a reference for the clinical diagnosis and treatment of COVID-19.
通讯作者:
Dongliang LiDongliang Li, male, Director of Hepatobiliary Medicine, Chief Physician, Doctor of Internal Medicine, Postdoctoral Doctor of Infectious Diseases, Adjunct Professor of Xiamen University, Master's Supervisor, currently Deputy Director of Fujian Infectious Disease Branch, Vice-chairman of Hepatology Branch of Fujian Society of Integrated Traditional Chinese and Western Medicine, Standing Member of Fujian Hepatology Branch, Head of the Fever Group, Infectious Diseases Branch, Fujian Province. He has obtained ten key projects and funds, including the China Postdoctoral Fund, National Natural Science Fund of China, the Natural Science Foundation of Fujian Province, the Medical Science and Technology Innovation Fund of the Nanjing Military Region, and the Fujian Provincial Key Projects. Dr. Li has published more than 50 academic papers, ten papers included in SCI, edited and participated in the preparation of 5 medical monographs, and won 1 military science and technology progress award. During the "11th five-year plan" period, he was listed as the discipline leader training object of the "122 Projects" for the cultivation of medical professionals in the military command and completed the program. He was awarded the a-level excellent teacher of the second military medical university in 2010. He is currently undertaking one international multi-center clinical trial.
引用本文:
Dongliang Li, Jia Ye, Yunhua Yu, Guoqing Yu, Chuanshen Jiang, Xianliang Lin, Wenfeng Lin, Youguang Lu. Analysis and Interpretation of Detection Results of Novel Coronavirus Nucleic Acids and Specific Antibodies[J]. 中国生物医学工程学报(英文版）, 2020, 29(1): 34-38.
Dongliang Li, Jia Ye, Yunhua Yu, Guoqing Yu, Chuanshen Jiang, Xianliang Lin, Wenfeng Lin, Youguang Lu. Analysis and Interpretation of Detection Results of Novel Coronavirus Nucleic Acids and Specific Antibodies. Chinese Journal of Biomedical Engineering, 2020, 29(1): 34-38.
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