A Novel Synthetic Analogue of Curcumin, B7, Inhibits Inflammatory Factors Expression in H2O2 Induced Endothelial Cells
WEI Dang-heng1, LIU Yang-hui1, JIA Xiao-ying1, GUO Feng-xia1, WU Jiang-zhang2
1. The Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hunan Province Hengyang 421001, China; 2. School of Pharmacy, Wenzhou Medical College, Zhejiang Province Wenzhou 325035, China
Abstract：Curcumin, a dietary phytochemical, exhibits multifunctional natural product with regulatory effects on inflammation. However, the poor bioavailability limits its clinical applications. Thus, we designed and synthesized a novel monocarbonyl analogue of curcumin B7 and their inhibition against monocyte chemotactic protein-1 (MCP-1) and interleukin-8(IL-8) release was evaluated in H2O2-stimulated human vascular endothelial cells (ECs) in a dose-responsive manner, while exhibiting no cytotoxicity in ECs. Taken together, these insights on the novel compound B7 may serve as potential agents for the treatment of atherosclerosis.
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