Noninvasive Brain Neuromodulation Based on Low-Intensity Focused Ultrasound Stimulation
YI Yuan1, MA Zhi-tao1, WANG Li-fang2, LI Xiao-li3, 4
1.Institute of Electrical Engineering, Yanshan University, Hebei Province Qinhuangdao 066004, China;
2.Office of Science and Technology Admini stration, Yanshan University, Hebei ProvinceQinhuangdao 066004, China;
3.State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;
4.Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China
Abstract：Low-intensity focused ultrasound stimulation (FUS), which possesses high spatial resolution and penetration depth, has been developing rapidly for noninvasive brain neuromodulation in recent years. In this letter, a low-intensity FUS system was developed for noninvasive brain neuromodulation in vivo. The radius of ultrasonic focal spot was quantitatively calculated in theory to evaluate the spatial resolution. The local field potential (LFP) of rat hippocompus were recorded before and after FUS. The effect of FUS on LFP power spectrum was investigated by computing the LFP mean absolute power and relative power with Welch algorithm. The experiment results show that noninvasive FUS can enhance LFP mean absolute power and alter the LFP relative power at different frequency bands. The results indicate that FUS can modulate brain rhythms and has significant potential in the modulation of neuronal and psychiatric diseases.
. [J]. 中国生物医学工程学报(英文版）, 2017, 26(4): 139-145.
YI Yuan, MA Zhi-tao, WANG Li-fang, LI Xiao-li. Noninvasive Brain Neuromodulation Based on Low-Intensity Focused Ultrasound Stimulation. Chinese Journal of Biomedical Engineering, 2017, 26(4): 139-145.
[1] Lefaucheur JP. Methods of therapeutic cortical stimulation[J]. Clinical Neurophysiology, 2009, 39:1-14.
[2] Bystritsky A, Kerwin L, Feusner J. A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder[J]. Journal of Clinical Psychiatry, 2008, 69(3): 412-417.
[3] DeGiorgio AM, Murray D, Markovic D, et al. Trigeminal nerve stimulation for epilepsy: long-term feasibility and efficacy[J]. Neurology, 2009, 72(10): 936.
[4] Muller PA, Pascual-Leone A, Rotenberg A. Safety and tolerability of repetitive transcranial magnetic stimulation in patients with pathologic positive sensory phenomena: A review of literature[J]. Brain Stimulation, 2012, 5(3): 320-329.
[5] Tyler WJ. Noninvasive neuromodulation with ultrasound? A continuum mechanics hypothesis[J]. Hypothesis, 2011, 17(1): 25-36.
[6] Younan Y, Deffieux T, Larrat B, et al. Influence of the pressure field distribution in transcranial ultrasonic neurostimulation[J]. Medical Physics, 2013, 40(8): 082902.
[7] Tufail Y, Yoshihiro A, Pati S, et al. Ultrasonic neuromodulation by brain stimulation with transcranial ultrasound[J]. Nature Protocols, 2011, 6(9): 1453-1470.
[8] Newton HE. The effect of high frequency sound waves on heart muscle and other irritable tissues[J]. American Journal of Physiology, 1929, 91(1): 284.
[9] Mihran RT, Barnes FS, Wachtel H, Temporally-specific modification of myelinated axon excitability in vitro following a single ultrasound pulse[J]. Ultrasound in Medicine & Biology, 1990, 16(3): 297-309.
[10] Oralkan M, Khuri-Yakub PT. Precise neural stimulation in the retina using focused ultrasound[J]. Journal of Neuroscience, 2013, 33(10): 4550-4560.
[11] Tufail Y, Matyushov A, Baldwin N, et al. Transcranial pulsed ultrasound stimulates intact brain circuits[J]. Neuron, 2010, 66(5): 681-694.
[12] Deffieux T, Younan Y, Wattiez N, et al. Low-intensity focused ultrasound modulates monkey visuomotor behavior[J]. Current Biology, 2013,23(23): 2430.
[13] Legon W, Sato TF, Opitz A, et al. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans[J]. Neurosurgery, 2014, 74(6): 322.
[14] King RL, Brown JR, Newsome WT, et al. Effective parameters for ultrasound-induced in vivo neurostimulation[J]. Ultrasound in Medicine & Biology, 2013, 39(2): 312-331.
