Dosimetry Study of High Dose Rate Flattening Filter-Free Radiation on the Protection of Lumbosacral Spine and Pelvic Bone Marrow
Xiufeng Cong1, Jun Chen1, Xiaoting Zhang1, Zaiming Lu2*
1. Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110042, 2. Liaoning China (Xiufeng Cong, Jun Chen, Xiaoting Zhang)Correspondence: Zaiming Lu, Department of radiology, Shengjing Hospital of China Medical University.
Dosimetry Study of High Dose Rate Flattening Filter-Free Radiation on the Protection of Lumbosacral Spine and Pelvic Bone Marrow
Xiufeng Cong1, Jun Chen1, Xiaoting Zhang1, Zaiming Lu2*
1. Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang 110042 2. Liaoning China (Xiufeng Cong, Jun Chen, Xiaoting Zhang)Correspondence: Zaiming Lu, Department of radiology, Shengjing Hospital of China Medical University.
摘要Objective This study aimed to analyze the dosimetric parameters of volumetric modulated arc therapy (VMAT) and dynamic multileaf collimator (DMLC) plans with lumbosacral spine (LS) and pelvic bone marrow (PBM) sparing in the flattening filter-free (FFF) model.Methods Thirty patients with cervical cancer were selected for analysis. For each patient, four plans with different strategies were generated: VMAT_FF, VMAT_FFF, DMLC_FF, and DMLC_FFF. Dose volumes for organs at risk, conformity index, heterogeneity index (HI), and total number of machine unit (MU) were compared by paired t-test.Result Compared with plans in the FF model, the irradiated dose to LS significantly decreased both VMAT_FFF and DMLC_FFF plans in the FFF model while the MU increased. The mean dose of LS decreased by 107.2 cGy (P<0.05) in the VMAT_FFF plan. In comparison with the VMAT plans in both models of FF and FFF, the DMLC plans reduced the dose volume of 10 Gy by 5.9% (P<0.05), and the mean dose of LS was 189.6-293.1 cGy. The PBM volume receiving 40 Gy showed a decrease of 0.5%-1.1% (P<0.05) as well. The HI increased in the VMAT plans by approximately 0.053 and 0.039.Conclusion The DMLC plans exhibited the best sparing of the PBM and LS in both FF and FFF models and increased the HI. The plans in the FFF model could limit the volume dose of LS but increase the MU.
Abstract：Objective This study aimed to analyze the dosimetric parameters of volumetric modulated arc therapy (VMAT) and dynamic multileaf collimator (DMLC) plans with lumbosacral spine (LS) and pelvic bone marrow (PBM) sparing in the flattening filter-free (FFF) model.Methods Thirty patients with cervical cancer were selected for analysis. For each patient, four plans with different strategies were generated: VMAT_FF, VMAT_FFF, DMLC_FF, and DMLC_FFF. Dose volumes for organs at risk, conformity index, heterogeneity index (HI), and total number of machine unit (MU) were compared by paired t-test.Result Compared with plans in the FF model, the irradiated dose to LS significantly decreased both VMAT_FFF and DMLC_FFF plans in the FFF model while the MU increased. The mean dose of LS decreased by 107.2 cGy (P<0.05) in the VMAT_FFF plan. In comparison with the VMAT plans in both models of FF and FFF, the DMLC plans reduced the dose volume of 10 Gy by 5.9% (P<0.05), and the mean dose of LS was 189.6-293.1 cGy. The PBM volume receiving 40 Gy showed a decrease of 0.5%-1.1% (P<0.05) as well. The HI increased in the VMAT plans by approximately 0.053 and 0.039.Conclusion The DMLC plans exhibited the best sparing of the PBM and LS in both FF and FFF models and increased the HI. The plans in the FFF model could limit the volume dose of LS but increase the MU.
基金资助:General program of National Natural Science Foundation of China, 31371425, microRNA regulates the mechanism of mitochondrial fusion protein OPA1 involved in apoptosis induced by chemotherapy drugs Special fund of NSFC director, 31240025, regulation of mitochondrial injury on apoptosis induced by sorafenib
通讯作者:
Zaiming Lu, born in 1971; working unit: Department of Radiology, Shengjing Hospital Affiliated to China Medical University; education background: doctor; degree: doctor; Title: Professor; position: chief physician; major: radiology and interventional medicine, chair of National Natural Science gene project, vice chairman of Provincial Medical Association, deputy director of Provincial Key Laboratory.E-mail:luzaiming@sina.com
作者简介: Xiufeng Cong, born in 1981, doctor of medicine, attending physician, graduated from clinical medicine English class of China Medical University in 2006. She is a member of IASLC of International Lung Cancer Association. She is now working in the oncology Department of Shengjing Hospital Affiliated to China Medical University. She is engaged in radiotherapy, chemotherapy, targeted therapy and other comprehensive treatment of tumors, and has published many journal articles at home and abroad.
引用本文:
Xiufeng Cong, Jun Chen, Xiaoting Zhang, Zaiming Lu. Dosimetry Study of High Dose Rate Flattening Filter-Free Radiation on the Protection of Lumbosacral Spine and Pelvic Bone Marrow[J]. 中国生物医学工程学报(英文版）, 2020, 29(1): 9-15.
Xiufeng Cong, Jun Chen, Xiaoting Zhang, Zaiming Lu. Dosimetry Study of High Dose Rate Flattening Filter-Free Radiation on the Protection of Lumbosacral Spine and Pelvic Bone Marrow. Chinese Journal of Biomedical Engineering, 2020, 29(1): 9-15.
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